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IRCT20190406043175N7 IRCT 2022-07-27 Mashhad University of Medical Sciences Persimmon extract toothpaste in treatment of gingivitis Evaluation of the effectiveness of toothpaste containing persimmon extract in the treatment of patients with gingivitis 2022-09-29 anticipated 56 Complete https://irct.ir/trial/64484 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this clinical trial, 56 patients were assigned to the dental faculty with gingivitis. The informed consent was completed and included the study. By using simple randomization method, a number of cards are selected by the researcher as the first group and the same number of cards for the next group. Then, by merging the cards together (by adding the cards), a card is taken out and its allocation is recorded, and that card is returned to the other cards by merging the cards together (by adding the cards). The cards then merge again and another card will have picked up. This process continues to reach a random sequence according to sample size. The patients divided equally into two groups of drugs (toothpaste containing persimmon extract), control toothpaste, Blinding description: In this double-blind study mouthwash is given to patients non-labeled, and the periodontist is unaware of which toothpaste is given to each group.Few drops of standard edible brown color will be added to the toothpaste of the control group. 2 Gingivitis. Intervention 1: Intervention group: toothpaste containing extract of persimmon. For each patient, toothpaste of persimmon extract two times a day for 4 weeks is administered. Persimmon extract is prepared by pharmacological research center of medical plants. The indices are evaluated in one month later by periodontist. Intervention 2: Control group: Control toothpaste two times a day for 4 weeks is administered. The indices are evaluated in one month later by periodontist. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Fatemeh Forouzanfar
Mashhad University of Medical Sciences, Azadi square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2538 forouzanfarf@mums.ac.ir Mashhad University of Medical Sciences scientific Fatemeh Forouzanfar
Mashhad University of Medical Sciences, Azadi square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2538 forouzanfarf@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Gingivitis Patients 18 years 65 years Both Pregnant or lactating women Allergic to oral hygiene products K05.1 Chronic gingivitis Treatment - Drugs Treatment - Drugs Intervention group: toothpaste containing extract of persimmon. For each patient, toothpaste of persimmon extract two times a day for 4 weeks is administered. Persimmon extract is prepared by pharmacological research center of medical plants. The indices are evaluated in one month later by periodontist. Control group: Control toothpaste two times a day for 4 weeks is administered. The indices are evaluated in one month later by periodontist. Gingivitis index. Timepoint: At baseline, and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe. Plaque index. Timepoint: At baseline, and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe. Pocket depth. Timepoint: At baseline, and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe. Mashhad University of Medical Sciences Approved 2022-03-06 Ethics committee of dentistry school, Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Azadi Square, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)