IRCT20220706055402N1 IRCT 2022-08-01 Ahvaz University of Medical Sciences dexmedetomidine in colonoscopy Evaluation of hemodynamic changes of dexmedetomidine in comparison with ketamine in patients undergoing colonoscopy under sedation with propofol 2022-07-20 anticipated 70 Complete https://irct.ir/trial/64746 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the classification of the subjects is done by the four-point permutation block method.In this method, A represents the person who receives the intervention and B represents the person who is placed in the control group. Code 1, abba code 2, BAAB code 3, BBAA code 4 and BABA code 5 to 9. 21 Numbers are considered as rows or columns. 138 people will be divided into two groups, Blinding description: After selecting the samples, the participants in the study, the endoscopic physician and the principal investigator are not aware of the allocation method and the drugs are injected by an anesthesiologist who is aware of the allocation and the data collection is done by them. 3 colonoscopy,sedation. Intervention 1: The intervention group will use propofol with a dose of 0.5 mg per kg and dexmedetomidine with a dose of 1 mg per kg and at a rate of 0.5 mg per kg per hour manufactured by Daro Farah Iran Company. Intervention 2: Intervention group: Propofol is given at a dose of 0.5 mg per kg and ketamine at a dose of 0.5 mg per kg. No - There is not a plan to make this available Justification or reason for not sharing IPD is After the study will be determined