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IRCT20220720055503N1 IRCT 2022-07-22 Hamedan University of Medical Sciences Comparison of the effects of topical spironolactone solution and topical clindamycin solution on mild to moderate acne vulgaris treatment Comparison of the effects of topical spironolactone solution and topical clindamycin solution on mild to moderate acne vulgaris treatment in Sina hospital, Hamadan 2022-07-22 anticipated 80 Complete https://irct.ir/trial/64877 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization method was used for randomization. Participants are placed in blocks of 8. First, the block number is selected among the 8 balls (numbered 1 to 8) in the lottery container. The order of placement of people in group A or B in blocks 1 to 10 has already been determined randomly by the sealed envelope website, Blinding description: The pharmacologist who is in charge of preparing the drugs knows what group A and group B drugs are, and she sticks the label A or B on the prepared drugs and delivers them to the researcher, so the participant, researcher and outcome evaluator are blind. 3 Acne Vulgaris. Intervention 1: Intervention group: Treatment with 2% spironolactone topical solution made by an experienced pharmacist twice a day for 3 months. Intervention 2: Control group: Treatment with 2% clindamycin topical solution made by an experienced pharmacist twice a day for 3 months. Yes - There is a plan to make this available What will be shared: All data after de-identification When: 6 months after the results are published To whom: Researchers working in academic institutions Conditions: The topic of the researcher's study is related to the topic of this study and has a code of ethics Where to obtain: Somayeh Zare M.D. somi.0006@gmail.com Bahareh Ebrahimi M.D. b.ebrahimi.4362@gmail.com How to obtain: Send the application, the title of the study and ethical documents via email, and after checking, the data will be emailed to her within one month at the latest Comments:
public Bahareh Ebrahimi
Sina Hospital, Mirzadeh Eshghi Ave.
Hamedan Iran (Islamic Republic of) 6516848741 +98 81 3827 4192 b.ebrahimi.4362@gmail.com Hamedan University of Medical Sciences scientific Bahareh Ebrahimi
Sina Hospital, Mirzadeh Eshghi Ave.
Hamedan Iran (Islamic Republic of) 6516848741 +98 81 3827 4192 b.ebrahimi.4362@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) People with mild to moderate acne 18 years old and above 18 years no limit Both Pregnant and lactating women Known hypersensitivity to clindamycin History of using oral isotretinoin, laser or chemical peeling in the last 6 months History of taking oral estrogen compounds in the last 3 months History of using retinoid or antibiotics during the last month History of using antimicrobial soaps or topical peels during the last two weeks Chronic skin diseases such as psoriasis, lichen planus, vitiligo Weakness of the immune system or the use of immunosuppressive drugs L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: Treatment with 2% spironolactone topical solution made by an experienced pharmacist twice a day for 3 months Control group: Treatment with 2% clindamycin topical solution made by an experienced pharmacist twice a day for 3 months Acne Severity. Timepoint: Beginning of trial,1 month,2 months and 3 months after treatment. Method of measurement: Global Acne Grading System. Frequency and type of acne lesions. Timepoint: Beginning of trial,1 month,2 months and 3 months after treatment. Method of measurement: Counting type and number of lesions. Hamedan University of Medical Sciences Approved 2022-06-26 Ethics committee of Hamedan University of Medical Sciences Building 4, No. 22, Ostad Morad Hanife St., Honarestan Blv. Hamedan Hamadan Iran (Islamic Republic of)