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IRCT20161108030776N5 IRCT 2024-06-15 Kerman University of Medical Sciences The effect of Centella asiatica L. on cognitive disorders in MS MS The effect of Centella asiatica L. on cognitive impairments in patients with multiple sclerosis (MS) 2022-08-06 anticipated 96 Complete https://irct.ir/trial/64897 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Dividing the patients into two equal intervention and control groups was done using the quadruple random block method. The codes of the patients were provided to the biostatistics specialist and were not opened until the end of the intervention period of the last patient and the analysis, Blinding description: After packaging, the drug and placebo were coded as A and B by the pharmacist. These codes were attached with a label on the drug and placebo package, and only the pharmacist and the biostatistician knew how to assign these codes to the drug and placebo. Then they were provided to the researcher. Neither the researcher nor the patient knew how to assign the codes to the drug or placebo. Finally, the codes and data are given to the statistician and the analysis is done. 3 Multiple sclerosis (MS). Intervention 1: Intervention group: Every 12 hours after meals, they received a capsule containing Centella asiatica plant powder for two months. Intervention 2: Control group: Every 12 hours after meals, they received a capsule containing starch, which is exactly the same as the drug group, for two months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the confidentiality of the information at this time
public Mohadese Kamali
Faculty of Persian medicine, University of Medical Sciences campus, the beginning of Haft Bagh Alavi axis
کرمان Iran (Islamic Republic of) 7616913555 +98 34 3133 6000 mohadesekamali0912@gmail.com Kerman University of Medical Sciences scientific Mohadese Kamali
Faculty of Persian medicine, University of Medical Sciences campus, the beginning of Haft Bagh Alavi axis
Kerman Iran (Islamic Republic of) 7616913555 +98 34 3133 6000 mohadesekamali0912@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Multiple sclerosis patients with complaints of cognitive impairment referred to the MS clinic and had proven cognitive impairment based on the BICAMS (brief international cognitive assessment for MS) test. no limit no limit Both Suffering from psychiatric diseases such as severe depression, schizophrenia, etc. pregnancy breastfeeding G35-G37 Demyelinating diseases of the central nervous system Treatment - Drugs Treatment - Drugs Intervention group: Every 12 hours after meals, they received a capsule containing Centella asiatica plant powder for two months. Control group: Every 12 hours after meals, they received a capsule containing starch, which is exactly the same as the drug group, for two months. Severity of cognitive impairment. Timepoint: Investigation of cognitive impairment at the beginning of the study (before the start of the intervention) and two months after the start of the intervention with the Centella asiatica. Method of measurement: BICAMS questionnaire. Quality of Life. Timepoint: At the beginning of the study (before the start of the intervention) and two months after the start of Centella Asiatica. Method of measurement: MSQOL54 questionnaire. Possible side effects. Timepoint: At the end of the study. Method of measurement: Registration by the patient and questions from the patient. Kerman University of Medical Sciences Approved 2022-04-16 Kerman University of Medical Sciences University of Medical Sciences campus, the beginning of Haft Bagh Alavi axis Kerman Kerman Iran (Islamic Republic of)