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IRCT20120520009801N8 IRCT 2022-07-30 Mashhad University of Medical Sciences Effect of rose hip on coronary slow flow The effect of rose hip alcoholic extract on transthoracic Doppler echocardiography parameters in patients with coronary slow flow 2022-09-23 anticipated 30 Complete https://irct.ir/trial/64960 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method used to generate a random allocation sequence with a guarantee of equal allocation of individuals to the two groups is a permutation block created using the website www.randomization.com. With the explanation that each block has 4 members and the shape of the blocks is as follows: [AABB], [ABAB], [ABBA], [BABA], [BBAA], [BAAB] Code A belongs to the intervention group and code B belongs to the control group. Therefore, 18 quadruple blocks were randomly generated by the site and patients were assigned to two study groups based on the sequence obtained from the above blocks, Blinding description: The allocation concealment method is using opaque sealed envelopes with random sequences obtained from the random allocation step. The codes are given to the researcher present in the hospital. This researcher is fully aware of the type of codes. Medications are also given to him on the basis of the number (A or B) and he is fully aware of which drug or placebo. At the end of study, the evaluator (physician) who does not know which drug the patient has received and is aware only of the assigned code, performs the relevant evaluations and after registration, the results are given to the person who performs data analysis. 3 Coronary artery slow flow syndrome. Intervention 1: Intervention group: tablets containing 250 mg of hydroalcoholic extract of rose hip prepared in the pharmacognosy and pharmaceutical laboratory of Mashhad Faculty of Pharmacy, 4 tablets daily oral for 2 months. Intervention 2: Control group: Placebo tablets prepared in the pharmaceutical laboratory of the Mashhad Faculty of Pharmacy, 4 tablets daily oral for 2 months. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentifiable individuals When: starting 6 months after publication To whom: People working in academic institutions Conditions: Mention the source Where to obtain: Amir Hoshang Mohammadpour Phone number: 0098 9153162909 Email: MohamadpoorAH@mums.ac.ir How to obtain: Reply to email within a maximum of one week Comments:
public Amir Hooshang Mohammadpour
School of Pharmacy, Mashhad University of Medical Sciences
Mashhad Iran (Islamic Republic of) 6519472972 +98 51 1882 3255 mohamadpoorah@mums.ac.ir Mashhad University of Medical Sciences scientific Amir Hooshang Mohammadpour
School of Pharmacy, Mashhad University of Medical Sciences
Mashhad Iran (Islamic Republic of) 6519472972 +98 51 1882 3255 mohamadpoorah@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Diagnosis of slow flow review based on angiography results CTFC (corrected TIMI frame count) > 27 Obtaining the consent of the patient or the patient's companion no limit no limit Both Aneurysm in the coronary arteries Patients with hyperhomocysteinemia Patients with myocarditis Patients with pericarditis Patients with cardiomyopathy The presence of ectasia in epicardial coronary vessels Not having a suitable view for electrocardiography Pregnancy or lactation Kidney or liver failure I20.8 Other forms of angina pectoris Treatment - Drugs Placebo Intervention group: tablets containing 250 mg of hydroalcoholic extract of rose hip prepared in the pharmacognosy and pharmaceutical laboratory of Mashhad Faculty of Pharmacy, 4 tablets daily oral for 2 months Control group: Placebo tablets prepared in the pharmaceutical laboratory of the Mashhad Faculty of Pharmacy, 4 tablets daily oral for 2 months PDV (peak diastolic velocity). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. MDV (mean diastolic velocity). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. PDP (peak diastolic pressure). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. MDP (mean diastolic pressure). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. Dvti(diastolic time velocity). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. Dint (diastolic flow interval). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. VTI (time velocity integral). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. LVEF (left ventricular ejection fraction). Timepoint: at baseline and two months after intervention. Method of measurement: Echocardiography. Adverse reactions of rose hip tablet. Timepoint: Two months after intervention. Method of measurement: Questionnaire. Mashhad University of Medical Sciences Approved 2022-06-11 Ethics committee of Mashhad University of Medical Sciences Vice Chancellor for Research and Technology, Third floor of Ghoreshi building, Next to Hoveyzeh Cinema, Daneshgah Street, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)