<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20220626055276N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2022-09-27</date_registration>
      <primary_sponsor>Research and Technology Vice-Chancellor of Shahrekord University</primary_sponsor>
      <public_title>The Effect of Weightlifting Training with Adding Respiratory Dead Space on angiogenesis</public_title>
      <acronym></acronym>
      <scientific_title>The effect of 10 weeks of weightlifting training with added respiratory dead space volume on angiogenic factors in young weightlifters</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2022-10-22</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>20</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/65042</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Randomization description: First, a list of subjects is prepared according to the inclusion criteria and available sampling, after determining the sample size with G power software, 20 people are selected by simple random method and random digits table. First, each person in the list is given a two-digit code, and then randomly, blindfolded and using a finger, we start from a point in the table of random numbers in the direction of the row or column, and we choose a number that is actually the code of a person from the list. which is chosen as a sample and we place them equally in two groups so that the first code is placed in the first group and the second code is placed in the second group and we continue in the same way until reaching the desired sample size.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Angiogenesis in male weightlifters.</hc_freetext>
      <i_freetext>Intervention 1: Intervention group: Intervention group: exercise group with mask and tube. Using an oxygen mask with a ventilator tube 2.5 cm in diameter and 204 cm long to provide 1000 ml of dead space is used by this group during weightlifting exercises. Intervention 2: Control group: exercise group without mask and tube. This group will do their weightlifting exercises without using masks and tubes.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>No - There is not a plan to make this available</results_IPD_plan>
      <results_IPD_description>Justification or reason for not sharing IPD is Each person's data alone is useless.</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Samira Nasiri</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Unit 2, 5th Floor, Danesh pazhohan building, Daneshjou Blvd</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>1984845497</zip>
        <telephone>+98 21 2243 4457</telephone>
        <email>Sa_nasiri@ymail.com</email>
        <affiliation>The University of Shahrekord</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Ebrahim Banitalebi</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Faculty of Sport Sciences, Shahrekord University, Rahbar Blvd., Shahrekord</address>
        <city>Shahrekord</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>8818634141</zip>
        <telephone>+98 38 3232 1631</telephone>
        <email>banitalebi@sku.ac.ir</email>
        <affiliation>The University of Shahrekord</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Weightlifter boys 18 to 25 years old
Have a body mass index between 19 to 25 with a body fat percentage of 12 to 15%
Have a history of weightlifting training for at least six months</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>25 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria>History of chronic disease (no diabetes, Blood pressure, chronic lung disease, etc.)
History of smoking for at least the last six months
Musculoskeletal injury or complication
Use of medications and weight loss program or special diet
The use of energizers or anabolic steroids even in therapeutic discussions before starting</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Other</i_code>
      <i_code>Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention group: Intervention group: exercise group with mask and tube. Using an oxygen mask with a ventilator tube 2.5 cm in diameter and 204 cm long to provide 1000 ml of dead space is used by this group during weightlifting exercises.</i_keyword>
      <i_keyword>Control group: exercise group without mask and tube. This group will do their weightlifting exercises without using masks and tubes.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Serum concentration of vascular endothelial growth factor. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by taking blood and measuring with diagnostic kits. Its unit is pg/ml.</prim_outcome>
      <prim_outcome>Serum concentration of Hypoxia-inducible factor. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by taking blood and measuring with diagnostic kits. Its unit is pg/ml.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Serum concentration of nitric oxide factor. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by taking blood and measuring with diagnostic kits. Its unit is µmol/l.</sec_outcome>
      <sec_outcome>Serum lactate concentration. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by taking blood and measuring with diagnostic kits. Its unit is mg/dl.</sec_outcome>
      <sec_outcome>Blood carbon dioxide partial pressure. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by drawing blood with a sterile syringe containing heparin anticoagulant and using an Arterial blood gas measuring device. Its unit is mm[Hg].</sec_outcome>
      <sec_outcome>Blood bicarbonate level. Timepoint: Before and immediately after the first session - before and immediately after the last session - 48 hours after the last session. Method of measurement: It is done by drawing blood with a sterile syringe containing heparin anticoagulant and using an Arterial blood gas measuring device. Its unit is meq/L.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Research and Technology Vice-Chancellor of Shahrekord University</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2022-05-31</approval_date>
        <contact_name>Research Ethics committees of Shahrekord University</contact_name>
        <contact_address>Faculty of Literature and Human Sciences, Shahrekord University, Rahbar Boulevard Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
