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IRCT20211118053093N4 IRCT 2022-08-19 Shiraz University of Medical Sciences Riluzole in the control of obsession in bipolar patients Comparison of the effect of bipolar disorder treatment (Lithium+Olanzapin+Clonazepam) and placebo with Riluzole-containing regimen in controlling obsessive symptoms of bipolar patients 2022-08-22 anticipated 40 Complete https://irct.ir/trial/65044 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Participants do not know which group they are in. The data analyser does not know which group it is analysing. The number of weeks of drug use is the same, so the patient is blinded to the type of treatment.Data analysis is given only data and does not know what treatment was done for witch group. 2 BMD. Intervention 1: Intervention group: It includes 20 patients who receive riluzole in addition to the main drugs, and in weeks 0, 4, 8, 12, and 16, they must complete the Yale Brown Obsessive Compulsive Scale questionnaire. Intervention 2: Control group: It includes 20 patients who receive a placebo in addition to the main drugs. And in weeks 0, 4, 8, 12, and 16, they must complete the Yale Brown Obsessive Compulsive Scale questionnaire. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Leila Razeghian Jahromi
13 km Shiraz-Isfahan, Ostad Mehrari Hospital
Shiraz Iran (Islamic Republic of) 71441-13331 +98 71 3260 5701 leilarazeghian1366@gmail.com Shiraz University of Medical Sciences scientific Leila Razeghian Jahromi
13 km Shiraz-Isfahan, Ostad Mehrari Hospital
Shiraz Iran (Islamic Republic of) 71441-13331 +98 71 3260 5701 leilarazeghian1366@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Having DSM 5 criteria for bipolar disorder Having a score higher than 18 in the Y_BOCS test no limit no limit Both Pregnancy Addiction Medical problems F31 Bipolar disorder Treatment - Drugs Treatment - Other Intervention group: It includes 20 patients who receive riluzole in addition to the main drugs, and in weeks 0, 4, 8, 12, and 16, they must complete the Yale Brown Obsessive Compulsive Scale questionnaire. Control group: It includes 20 patients who receive a placebo in addition to the main drugs. And in weeks 0, 4, 8, 12, and 16, they must complete the Yale Brown Obsessive Compulsive Scale questionnaire. Yale Brown Obsessive-Compulsive Scale score. Timepoint: week 0and4and8and12and16. Method of measurement: Yale Brown Obsessive-Compulsive Scale. Shiraz University of Medical Sciences Approved 2022-07-05 Ethics committee of Shiraz University of Medical Sciences Kilometer 13 of Shiraz-Isfahan highway, Ostad Moharreri Hospital Shiraz Fars Iran (Islamic Republic of)