IRCT20160702028742N12 IRCT 2022-09-03 Shahid Beheshti University of Medical Sciences Effect of zinc and vitamin E supplements on immune system cytokines Effect of co-administration of zinc and vitamin E supplements on plasma concentrations cytokines secreted by T-helper1, 2, and 17 in cardiac surgery patients: Randomized controlled trial 2022-08-27 anticipated 62 Complete https://irct.ir/trial/65143 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: Participants will be randomized to receive vitamin supplement or the placebo. To ensure that the study participants were balanced in two groups, stratified block randomization will be used. Stratification will be based on having/not having diabetes. In each stratum, randomization will be in blocks of four. The sequence of each block will be determined using random assignment software (RAS) with a 1:1 ratio between the two groups in the block. The allocation sequence is placed in an opaque envelope and they are numbered, and during the study they are opened sequentially and people are assigned to groups based on it, Blinding description: The researcher is aware of the type of supplements used, but due to similar shape and color, they cannot be distinguished by the patient. Also, those responsible for data collection and outcome assessment are blinded to the type of supplement used by the patient. N/A Coronary heart disease. Intervention 1: Control group: Placebo capsules produced by the pharmaceutical company producing the study supplements (Dana Pharmaceutical Company) and contain all the ingredients used in the supplement except the active ingredient (vitamin E or zinc) from the second day after surgery until the end of the study (3 weeks after surgery). Intervention 2: Intervention group: Zinc and vitamin E capsules (Vitamin E in 200 international units of alpha-tocopherol and zinc in the form of zinc gluconate in a dose of 40 mg, 5 days a week) from the second day after surgery until the end of the study (3 weeks after surgery). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.