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IRCT20220607055097N3 IRCT 2022-08-30 Nowshera Medical College/ Qazi Hussain Ahmad Medical Complex Topical Azithromycin and oral doxycycline in meibomian gland dysfunction Comparison of the efficacy of topical azithromycin with oral doxycycline in the treatment of meibomian gland dysfunction: A randomized clinical practice trial 2019-12-01 anticipated 60 Complete https://irct.ir/trial/65203 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Prospective, randomized clinical practice trial, Randomization description: Simple randomization, unit of randomization taken as individual, non-stratified, Tools used in randomization was table of random numbers, allocation concealment was not carried out. N/A Meibomian gland dysfunction. Intervention 1: Intervention group: Topical Azithromycin 1%, Twice daily for 1 week followed by once daily for 3 weeks. Intervention 2: Intervention group: Oral Doxycycline 100 mg, once daily for 4 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidential
public Adnan Ahmad
Civil colony
Peshawar Pakistan 25000 +92 91 2586506 dradnanahmad@hotmail.com Nowshera Medical College, Nowshera scientific Adnan Ahmad
Civil colony
Peshawar Pakistan 25000 +92 91 2586506 dradnanahmad@hotmail.com Nowshera Medical College, Nowshera Pakistan All the patients within the specified age group with posterior blepharitis secondary to meibomian gland dysfunction Patients with meibomian gland dysfunction, non responsive to conventional therapy such as lid massage, warm compresses and lid scrubbing 26 years 42 years Both Patients with blepharitis other than posterior one Patients with other inflammatory lid conditions like atopic blepharoconjunctivitis Patients with traumatic eyelid injuries Patients with neoplastic lid disorders Pregnant, conceiving and lactating females history of any allergy to the study drugs Patients treated with oral or topical medications other than study drugs for posterior blepharitis within 3 months period H01.0 Blepharitis Treatment - Drugs Treatment - Drugs Intervention group: Topical Azithromycin 1%, Twice daily for 1 week followed by once daily for 3 weeks Intervention group: Oral Doxycycline 100 mg, once daily for 4 weeks Mean improvement in symptoms score. Timepoint: Baseline, 2nd and 4th week. Method of measurement: Subjective symptoms including itchy eyes, grittiness, MG plugging, foreign body (FB) sensation and watering were recorded in a check list as 0 = asymptomatic, 1= moderate and 2 = severe symptoms. Mean improvement in corneal staining. Timepoint: Baseline, 2nd and 4th week. Method of measurement: For corneal staining, we divided the cornea into five regions and assigned a score of 1 for peripheral staining and 4 for staining of central cornea implying more severe involvement by the disease process. Mean improvement in bulbar conjunctival hyperaemia. Timepoint: Baseline, 2nd and 4th week. Method of measurement: For bulbar conjunctival hyperaemia, area was divided into six regions and scoring from 0 to 4 was done depending upon the number of involved regions. Mean improvement in Schirmer 1 test. Timepoint: Baseline, 2nd and 4th week. Method of measurement: Schemers 1 test (5 min. test without anesthesia) were performed in all of the participants, > 10 mm wetting was considered as normal. Nowshera Medical College/ Qazi Hussain Ahmad Medical Complex Approved 2019-11-20 Institutional Ethical Review Board of Nowshera Medical College Mardan road, near Kabul river, Nowshera Nowshera Khyber Pukhtoonkhwa Pakistan