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IRCT20160307026950N43 IRCT 2022-09-07 Esfahan University of Medical Sciences Comparative study of changes in heart rate and blood pressure in the use of Dosecam Ketamine with Dexmedetomidine and Dosecam Ketamine with Propofol in cataract surgery under local anesthesia by phacoemulsification method. Comparative study of changes in heart rate and blood pressure in the use of Dosecam Ketamine with Dexmedetomidine and Dosecam Ketamine with Propofol in cataract surgery under local anesthesia by phacoemulsification method. 2022-08-23 anticipated 60 Complete https://irct.ir/trial/65215 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are collected by easy and continuous sampling method. . Then the samples were randomly divided into two groups by computer randomization using relevant software. Sampling continues until the samples reach the set limit. Sampling is done using unique codes and they are placed in 2 groups a or b. People who take the first combination of ketamine with dexmedetomidine in group a and people who take the second combination of medicine with dexmedetomidine and group b are placed in the group of the second combination of medicine and ketamine with propofol, Blinding description: The method of blinding is that patients are unaware of the type of drug they are given and drugs provided in similar syringes and coded for those by the researcher and given to the study expert to inject. and the hemodynamic changes are monitored and recorded, so the attending, the clinical caregiver, the examiner, and the data analyzer will not understand the type of medication and the investigator deciphers the codes after data analysis. 3 Condition 1: heart rate. Condition 2: Hypotension. Intervention 1: Intervention group: Intervention group: First, informed consent is obtained from the patients. After placing the patients on the bed of the operating room, standard monitoring including blood pressure gauges and basic vital signs are recorded. Ketamine is injected intravenously with dexmedetomidine to the patient, the desired variables are recorded at the desired times. Intervention 2: Intervention group: First, informed consent is obtained from the patients. After placing the patients on the bed of the operating room, standard monitoring including blood pressure gauges and basic vital signs are recorded. Ketamine is injected intravenously with dexmedetomidine to the patient, the desired variables are recorded at the desired times. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Behzad Nazemroaya
Hezarjirib st, Isfahan, Iran
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3212 3543 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences scientific Behzad Nazemroaya
Hezarjirib st, Isfahan, Iran
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3212 3543 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients 18 years and older For the first time, they undergo cataract surgery using phacoemulsification be in ASA class 1 to 3 18 years no limit Both Patients with obstructive sleep apnea diabetes , mental illnesses , Autoimmune diseases Nystagmus Leukemia , epilepsy Patients treated with psychiatric drugs , Deafness Drug allergy Use of painkillers in the past week BMI index greater than 35 R00.1 I95 Bradycardia, unspecified Hypotension Treatment - Drugs Treatment - Drugs Intervention group: Intervention group: First, informed consent is obtained from the patients. After placing the patients on the bed of the operating room, standard monitoring including blood pressure gauges and basic vital signs are recorded. Ketamine is injected intravenously with dexmedetomidine to the patient, the desired variables are recorded at the desired times. Intervention group: First, informed consent is obtained from the patients. After placing the patients on the bed of the operating room, standard monitoring including blood pressure gauges and basic vital signs are recorded. Ketamine is injected intravenously with dexmedetomidine to the patient, the desired variables are recorded at the desired times. Heart rate. Timepoint: Before injecting anesthetic, one minute after injecting anesthetic, five minutes after injecting anesthetic, every ten minutes during surgery and every ten minutes during recovery until discharge. Method of measurement: NIBP Noninvasive Blood Pressure measurement by an anesthesiologist. Bloodpressure. Timepoint: Before injecting anesthetic, one minute after injecting anesthetic, five minutes after injecting anesthetic, every ten minutes during surgery and every ten minutes during recovery until discharge. Method of measurement: NIBP Noninvasive Blood Pressure measurement by an anesthesiologist. Esfahan University of Medical Sciences Approved 2022-05-08 Ethics Committee in Biomedical Research, Isfahan University of Medical Sciences Hezar Jarib Isfahan Isfehan Iran (Islamic Republic of)