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IRCT201103146067N1 IRCT 2011-05-04 Shiraz university of medical sciences The effect of conjugated linoleic acid and omega 3 fatty acids on patients with atheroscherosis. Evaluation the effect of conjugated linoleic acid and omega 3 fatty acids supplements on lipid profile, inflammatory factors and oxidative stress indices on patients with atherosclerosis 2011-02-11 anticipated 90 Complete https://irct.ir/trial/6524 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Heart disease. Intervention 1: Conjugated linoleic acid intake,3000 mg per day, for 2months , 3 capsule per day, each capsule contain 1000mg cnjugated linoleic acid. Intervention 2: Omega 3 fatty acids intake,1920mg per day for 2 months , 3 capsule per day, each capsule contain 640 mg,omega3 fatty acids. Intervention 3: Placebo intake for 2 months , 3 capsule per day.
public fereshte aliasghari
Department of nutrition, School of health and nutrition, Shiraz University of Mediccal Sciences
shiraz Iran (Islamic Republic of) 7153675541 +98 71 1725 1001 f.aliasghary@yahoo.com School of health and nutrition, Shiraz University of Mediccal Sciences scientific Dr. Mohammad Hassan Eftekhari
Department of nutrition, School of health and nutrition, Shiraz University of Mediccal Sciences
Shiraz Iran (Islamic Republic of) 7153675541 +98 71 1725 1001 eftekharim@sums.ac.ir; h_efftekhari@yahoo.com School of health and nutrition, Shiraz University of Mediccal Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with Atherosclerosis with Age more than30 years old, 24.5>Body Mass Index>18.5, use of stable dosage medication for hyperlipidemia in study period, patients with history of stable angina, heart attack and bypass surgery. Exclusion criteria: Having Acute heart failure ، Arrhythmia, Acute complications of atherosclerosis, using any supplement such as vitamin C, E, Omega3 during and six months before the study, pregnancy , UVB exposure with therapeutic goals and diabetes mellitus 30 years no limit Both I25.1 بيماري قلبي آترواسكلروتيك Treatment - Drugs Treatment - Drugs Placebo Conjugated linoleic acid intake,3000 mg per day, for 2months , 3 capsule per day, each capsule contain 1000mg cnjugated linoleic acid Omega 3 fatty acids intake,1920mg per day for 2 months , 3 capsule per day, each capsule contain 640 mg,omega3 fatty acids Placebo intake for 2 months , 3 capsule per day Lipid profile. Timepoint: Before and after intervention. Method of measurement: Auto Analysor. GSH-X(Glutathione peroxidase). Timepoint: Before and after intervention. Method of measurement: ELIZA. MDA (Malondialdehyde). Timepoint: Before and after intervention. Method of measurement: Spectrophotometery. Hs-CRP(high sensetive c-reactive protein). Timepoint: Before and after intervention. Method of measurement: ELIZA. Interleukin 6. Timepoint: Before and after intervention. Method of measurement: RIA kit. Shiraz university of medical sciences Approved 2011-02-10 Shiraz University of Medical Sciences Shiraz University of Medical Sciences Shiraz Iran (Islamic Republic of)