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IRCT20220609055118N1 IRCT 2022-08-30 Esfahan University of Medical Sciences The effect of dienogest, Oral contraceptive pill(OCP), Decapeptyl treatment, and fresh transfer method on pregnancy outcomes in women with endometriosis IVF The effect of dienogest, Oral contraceptive pill(OCP), Decapeptyl treatment, and fresh transfer method after ovum pickup in IVF women candidates on pregnancy outcomes in women with endometriosis 2022-09-23 anticipated 88 Complete https://irct.ir/trial/65288 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, 88 eligible patients are randomly selected. For this, the letter A is written on 22 sheets, the letter B is written on 22 sheets, the letter C is written on 22 sheets, and the letter D is written on 22 sheets, and each of them is placed in an envelope. Then each patient is then asked to choose one of the envelopes. Depending on the selected envelope, the patient is assigned to one of three groups. 2 Endometriosis. Intervention 1: The first intervention group: Patients in this group were treated with dienogest at the rate of 2 mg/kg for 3 months, and then IVF was immediately performed on them. Intervention 2: The second intervention group: Patients in this group were treated with oral contraceptive pills (OCP) for 3 months, and then IVF was immediately performed on them. Intervention 3: The third intervention group: patients in this group were treated with decapeptyl 3.75 mg for 3 months; So that they receive a dose of medicine every 28 days. Then 15 days after the last dose, IVF is performed on them. Intervention 4: Fourth intervention group: For patients in this group, without receiving the above three drugs, embryo transfer is done fresh. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Hatav Ghasemi Tehrani
Department of Obstetrics and Gynecology, Al-Zahra Hospital, Sofeh Blvd., Tohid Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 tehrani@med.mui.ac.ir Esfahan University of Medical Sciences scientific Hatav Ghasemi Tehrani
Department of Obstetrics and Gynecology, Al-Zahra Hospital, Sofeh Blvd., Tohid Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 tehrani@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Infertile women Reproductive age 30-45 years Suffering from any of the stages 3 or 4 of endometriosis IVF candidate Consent to participate in the study 30 years 45 years Female Any drug sensitivity History of thromboembolic diseases, malignancy Positive family history for thrombophilia Contraindication of contraceptive use, GnRH agonist Prohibition of pregnancy Having infectious diseases such as hepatitis B, C or HIV N80 Endometriosis Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Other The first intervention group: Patients in this group were treated with dienogest at the rate of 2 mg/kg for 3 months, and then IVF was immediately performed on them. The second intervention group: Patients in this group were treated with oral contraceptive pills (OCP) for 3 months, and then IVF was immediately performed on them. The third intervention group: patients in this group were treated with decapeptyl 3.75 mg for 3 months; So that they receive a dose of medicine every 28 days. Then 15 days after the last dose, IVF is performed on them. Fourth intervention group: For patients in this group, without receiving the above three drugs, embryo transfer is done fresh. Level of human chorionic gonadotropin (B-HCG). Timepoint: After the intervention. Method of measurement: Urinalysis. Endometrial thickness. Timepoint: Before and after the intervention. Method of measurement: Sonography. Isfahan University of Medical Sciences Approved 2021-11-20 Ethics committee of Isfahan University of Medical Sciences Street address Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq Isfahan Isfehan Iran (Islamic Republic of)