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IRCT20170927036459N3 IRCT 2022-09-10 Islamic Azad University Effects of high-intensity interval training and L-Citrulline supplementation on neuromuscular indices in elders Effects of high-Intensity interval training combined with L-Citrulline supplementation on neuromuscular indices in elderly men with Sarcopenia 2022-09-01 anticipated 40 Complete https://irct.ir/trial/65333 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: At first, the subjects will be selected using a simple random method. Then, using a table of random numbers, they are divided into four groups. Therefore, each candidate will be assigned a two-digit number. Equal to the sample size, the same number of digits is determined for the selection of individuals (five-digit numbers whose last two digits are similar to the existing codes) that are randomly assigned to one of the groups It will be given. This will continue until the number of people in each group is completed. Therefore, the researcher will not have the option to change the status of the assignment or predict it. Random hiding will be done by a third party who does not participate in other stages of the intervention, Blinding description: The participants will be randomly allocated in to 4 groups and will not aware of the type of treatment. For this purpose, we informed each subject in the form of a confidential letter about all the tasks and their grouping requirements. We reported the status of the subject grouping through the code selected for each group and no group names were recorded in the subjects' letters. N/A Sarcopenia. Intervention 1: Intervention group: Exercise+Placebo: high intensity interval training performed for 8 weeks and 3 sessions per week that included 30 seconds cycling exercise on ergometer (intensity of 85-90% HR reserve). In addition, This group received one capsule similar (placebo) to supplement L-citrulline for 8 weeks. Intervention 2: Intervention group: Supplement group: L-citrulline supplement consumed in single 6 g-dose daily for 8 weeks. Intervention 3: Intervention group: Exercise+supplement group: participants of this group performed high intensity interval training performed for 8 weeks and 3 sessions per week that included 30 seconds cycling exercise on ergometer (intensity of 85-90% HR reserve). In addition, this group received L-citrulline supplement in single 6 g-dose daily for 8 weeks. Intervention 4: Control group: This group received one capsule (placebo) similar to supplement L-citrulline for 8 weeks. Yes - There is a plan to make this available What will be shared: A piece of data that contains information about variables that can be shared. When: Available period from 2022 To whom: Researchers Conditions: Statistical analysis on the data is not allowed. Where to obtain: Amin Farzaneh Hesari af.hessari@gmail.com How to obtain: The purposes and uses of the data should be clearly stated by the applicant. Comments:
public Amin Farzaneh Hesari
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Farah Abad road
Sari Iran (Islamic Republic of) 4816119318 +98 11 3317 5333 af.hessari@gmail.com Islamic Azad University scientific Amin Farzaneh Hesari
Department of exercise physiology, Sari Branch, Islamic Azad University, Farah abad road
Sari Iran (Islamic Republic of) 4816119318 +98 11 3317 5333 af.hessari@gmail.com Islamic Azad University Iran (Islamic Republic of) Aged 60-75 Having general physical and mental health Suffering from sarcopenia Man 60 years 75 years Male Having a history of chronic disease Inability to exercise Having regular exercise history (3 times a week, more than 30 minutes) Drug use or supplementation M62.5 Muscle wasting and atrophy, not elsewhere classified Placebo Other Other Placebo Intervention group: Exercise+Placebo: high intensity interval training performed for 8 weeks and 3 sessions per week that included 30 seconds cycling exercise on ergometer (intensity of 85-90% HR reserve). In addition, This group received one capsule similar (placebo) to supplement L-citrulline for 8 weeks. Intervention group: Supplement group: L-citrulline supplement consumed in single 6 g-dose daily for 8 weeks. Intervention group: Exercise+supplement group: participants of this group performed high intensity interval training performed for 8 weeks and 3 sessions per week that included 30 seconds cycling exercise on ergometer (intensity of 85-90% HR reserve). In addition, this group received L-citrulline supplement in single 6 g-dose daily for 8 weeks. Control group: This group received one capsule (placebo) similar to supplement L-citrulline for 8 weeks. Serum C-terminal agrin fragment peptide. Timepoint: Before and after eight weeks of intervention. Method of measurement: ELISA commercial kit. Balance. Timepoint: Before and after eight weeks of intervention. Method of measurement: Romberg test. Muscular strength. Timepoint: Before and after eight weeks of intervention. Method of measurement: Dynamometer. Functional ability. Timepoint: Before and after eight weeks of intervention. Method of measurement: Timed up and go test. Islamic Azad University Approved 2022-04-17 Ethics committee of Islamic Azad University- Sari branch Department of Exercise Physiology, Islamic Azad University of Sari, Farah Abad Road Sari Mazandaran Iran (Islamic Republic of)