IRCT20120629010133N5 IRCT 2022-09-10 Shahid Beheshti University of Medical Sciences The effect of increasing pulmonary ventilation in methanol poisoning iHV The effect of Isocapnic hyperventilation (iHV) on detoxification of methanol poisoned patients: A pilot study 2022-10-23 anticipated 30 Complete https://irct.ir/trial/65482 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Toxic alcohols. Intervention group: iHV. The concept of isocapnic hyperventilation (iHV) allows the person to hyperventilate while keeping the CO2 within normal limits at the same time. The ClearMate (Thornhill Research Inc., Canada) adds CO2 to the inspired air to compensate to the increased loss induced by the increased minute ventilation. This means that hyperventilation can occur, and a wash-out of volatile substances such as methanol will happen without disrupting the important CO2 balance. iHV increases the elimination of methanol to the extent that it could replace hemodialysis for elimination purposes when hemodialysis is not required for the correction of acidosis. Likewise, Alcohol Dehydrogenase (ADH), the responsible enzyme for methanol metabolization and further acidosis is completely blocked by Fomepizole during the intervention. Methanol serum level will be measured every 2 hours and iHV will be stopped if it is <5 mmol.. Yes - There is a plan to make this available What will be shared: Only main outcomes will be shared When: Sharing at the time of publication in a scientific journal To whom: Only for researchrs Conditions: It would be defined later Where to obtain: Via email How to obtain: Having a reasonable request, it takes almost one month Comments: No