IRCT20220329054367N2 IRCT 2022-11-06 Shahid Beheshti University of Medical Sciences Comparison of the effect of psychiatric drugs on the improvement of psychological symptoms and disease severity in patients with functional dyspepsia Comparison of the effect of duloxetine with nortriptyline on depression, anxiety, and quality of life in patients with functional dyspepsia 2022-09-23 anticipated 46 Complete https://irct.ir/trial/65512 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be assigned to two arms, using block randomization method. The block size is four, involving 3 patients (based on order’s coming) which would generated by online block randomization software “Sealed Envelope”. The list of random blocks will be placed in envelopes, daily would be opened by the staffs, Blinding description: Patients are evaluated at the end of the first month, the end of the second month and the end of the third month after the start of the examination by an interviewer who does not know which medicine the patient received. 4 functional dyspepsia. Intervention 1: Intervention group: In the first intervention group, 20 mg duloxetine (Cymbalta brand name) is prescribed for patients. Patients are advised to take the medicine with food. Patients should take this medicine for three months. Intervention 2: Intervention group: In the first intervention group, nortritiline drug with a dose of 25 mg (Aventyl brand name) is prescribed for the patients. Patients are advised to take the medicine with food. Patients should take this medicine for three months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of participants' data