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IRCT20220829055822N1 IRCT 2022-09-03 Mashhad University of Medical Sciences Evaluation of an anti sensitivity paste on teeth Evaluation and comparison of the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity: a randomized, triangular blinded clinical trial study 2022-06-22 anticipated 16 Complete https://irct.ir/trial/65545 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of applying the anti-sensitive paste in this study will be split-mouth, and the choice of the treated half of the jaw as control or intervention will be random, in such a way that each patient randomly chooses the type of treatment for his/her half of the jaw. Each patient receives a sealed envelope of 8 envelopes related to his/her gender group and determines his/her control and intervention half of the jaw, Blinding description: One person does the application of anti-sensitive paste, and the evaluation of sensitivity is done by another person who is unaware of the type of treatment for each half of the jaw. Also, the patient does not know the contents of the received envelope. Therefore, the patient, evaluator, and statistician are blind to the type of treatment. 3 tooth sensitivity, dental sensitivity. Intervention 1: Intervention group: In this group, the synthesized paste containing the active ingredient l-arginine/calcium carbonate 8% and potassium nitrate 3% was used. 2 times on 2 consecutive days, the paste was applied in the clinic for half an hour. It was refreshed one time during the process every day. A micro brush was used for the application process while isolating the side teeth. Due to the need for saliva and its enzymes, excessive drying of the oral environment was prevented. Intervention 2: Control group: In this group, the synthesized paste without the active ingredient l-arginine/calcium carbonate 8% and potassium nitrate 3% was used. 2 times on 2 consecutive days, the paste was applied in the clinic for half an hour. It was refreshed one time during the process every day. A micro brush was used for the application process while isolating the side teeth. Due to the need for saliva and its enzymes, excessive drying of the oral environment was prevented. Yes - There is a plan to make this available What will be shared: Participants: Basic information including name and age and information about the main outcome will be published. When: The access period starts 1 month after the results are published To whom: Due to the non-confidentiality of the information, its use is free for everyone. Conditions: Due to the non-confidentiality of the information, its use is free for everyone. Where to obtain: Arsalan Shahri How to obtain: It will be sent to the applicant within 4 working days. Comments:
public Arsalan Shahri
No.2 ,16th HakimNezami St.
Mashhad Iran (Islamic Republic of) 9175966333 +98 51 3844 5332 shahria951@mums.ac.ir Mashhad University of Medical Sciences scientific Arsalan Shahri
No.2 ,16th HakimNezami St.
Mashhad Iran (Islamic Republic of) 9175966333 +98 51 3844 5332 shahria951@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) • Patients who need anti-sensitive treatment of teeth without caries • Patients in good general and oral health conditions • Not having a history of illness or long-term drug use • People who do not use orthodontic appliances 18 years 50 years Both • The patient's unwillingness to continue cooperation • Non-attendance of the patient during visit sessions K08.8 Other specified disorders of teeth and supporting structures Treatment - Drugs Placebo Intervention group: In this group, the synthesized paste containing the active ingredient l-arginine/calcium carbonate 8% and potassium nitrate 3% was used. 2 times on 2 consecutive days, the paste was applied in the clinic for half an hour. It was refreshed one time during the process every day. A micro brush was used for the application process while isolating the side teeth. Due to the need for saliva and its enzymes, excessive drying of the oral environment was prevented. Control group: In this group, the synthesized paste without the active ingredient l-arginine/calcium carbonate 8% and potassium nitrate 3% was used. 2 times on 2 consecutive days, the paste was applied in the clinic for half an hour. It was refreshed one time during the process every day. A micro brush was used for the application process while isolating the side teeth. Due to the need for saliva and its enzymes, excessive drying of the oral environment was prevented. Dental sensitivity. Timepoint: before work; immediately after the application; 24 hours; A week; One month and three months after application. Method of measurement: For sensitivity to cold, an air-water syringe was used for 3 seconds at a distance of 1 cm from the tooth while isolating the side teeth. For palpation, the movement of the scaler probe was used in the CEJ region of the desired tooth. Finally, the VAS criterion was used to record the results. Mashhad University of Medical Sciences Approved 2022-04-06 Research Ethics Committees of School of Dentistry - Mashhad University of Medical Sciences No.2 , 16th Hakim St. Koohsangi Ave. Mashhad Razavi Khorasan Iran (Islamic Republic of)