IRCT20210923052559N1 IRCT 2022-10-11 Mashhad University of Medical Sciences The effect of oral black seed oil on knee osteoarthritis The effect of oral black seed oil capsule on serum level of Tenascin-C in knee osteoarthritis patients 2022-09-23 anticipated 80 Complete https://irct.ir/trial/65834 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization will be done by www.randomization.com website . Numbers will be placed in sealed envelopes and each envelope is assigned to one participant placing them in one of the two groups, Blinding description: The study subjects and those who evaluate the outcome in the participants as well as the final analyst of the collected data of the study will be unaware of the intervention and control groups due to the fact that the placebo is used in the study in parallel with the drug. 2-3 Knee osteoarthritis. Intervention 1: Intervention group: Patients in this group will take two black seed capsules per day (every 12 hours) for 3 months.Each capsule of black seed contains 5.3 mg of thymoquinone, the effective dose of which has anti-inflammatory effects and reduces the destruction of cartilage.The drug is prepared by Barij Essan Company.In addition to the routine treatment of osteoarthritis, which is the use of non-steroidal anti-inflammatory drugs in case of pain. Intervention 2: Control group: Patients in this group will take two placebo capsules (it will look similar to the medicine capsule) per day (every 12 hours) for 3 months.Placebo is also prepared by Barij Essan Company.In addition to the routine treatment of osteoarthritis, which is the use of non-steroidal anti-inflammatory drugs in case of pain. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is We will make a decision after finishing the work and consulting with the project colleagues.