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IRCT20220912055942N1 IRCT 2023-07-24 Tarbiat Modares University the effect of exercise on cognitive functions and gut microbiom The Effects of Multi-Component Exercise Training on Selected Intestinal Microbiomes, and Disease Status and Their Relationship with Cognitive Function in Elderly People with Type 2 Diabetes 2023-06-22 anticipated 100 Complete https://irct.ir/trial/65856 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Other, Purpose: Education/Guidance, Randomization description: The samples will be determined by the random block method with blocks of 4 and using the random number table of the random allocation software. Blocking and allocation sequence will be done for concealment by a person not involved in the research (allocation concealment). The allocation ratio of the samples will be one to one and they will be placed in two sports intervention and control groups. Then, based on the obtained blocks and according to the allocation sequence, the multiple exercise training program will be given to the exercise intervention group. Blinding will not occur in this study. N/A TYPE 2 DIABETES. Intervention 1: Intervention group: implementation of 12 weeks of combined sports training intervention that includes aerobic and strength training, balance, flexibility and cognitive training. The training will start from 3 days a week and will reach 5 days from the 9th week to the end of the 12th week, which includes walking. It is accompanied by cognitive exercises and weight or resistance exercises and yoga movements for balance and stretching the body. Intervention 2: Control group: NO EXERCISE. Yes - There is a plan to make this available What will be shared: Part of the data related to the main outcome can be shared. When: The access period starts 6 months after the results are published To whom: People approved by the supervisor Conditions: For the purpose of additional research in the field of the present study Where to obtain: supervisor How to obtain: E-mail correspondence with the supervisor molanouri@modares.ac.ir Comments:
public Dr. Mahdieh Melanori Shamsi
JALALE AL AHMAD
TEHRAN Iran (Islamic Republic of) 1411713116 +98 21 8288 4683 molanouri@modares.ac.ir Tarbiat Modares University of Tehran scientific Dr. Mahdieh Melanori Shamsi
JALAL E ALE AHMAD
TEHRAN Iran (Islamic Republic of) 1411713116 +98 21 8288 4683 molanouri@modares.ac.ir Tarbiat Modares University Iran (Islamic Republic of) Iran (Islamic Republic of) type 2 diabetes Age range 50-75 years 50 years 75 years Female Severe orthopedic or respiratory problems Severe cardiovascular patients Dementia Central nervous system disorders A special diet such as vegetarianism Carrying out a regular exercise program during the last 6 months E11.9 Type 2 diabetes mellitus without complications Other Other Intervention group: implementation of 12 weeks of combined sports training intervention that includes aerobic and strength training, balance, flexibility and cognitive training. The training will start from 3 days a week and will reach 5 days from the 9th week to the end of the 12th week, which includes walking. It is accompanied by cognitive exercises and weight or resistance exercises and yoga movements for balance and stretching the body. Control group: NO EXERCISE Examining intestinal microbiome factors such as Lactobacillus bacteria due to diabetes -. Timepoint: Measurement of stool microbiomes before the intervention and 12 weeks after the intervention. Method of measurement: Through stools of patients and extraction of DNA from stools by Fioragin kit. Executive function. Timepoint: Before and after 3 months intervention. Method of measurement: Trail Making Test. Respiratory and cardiovascular system, blood circulation and muscle. Timepoint: Trail Making Test. Method of measurement: 6-Minute Walk Test. Body Mass Index. Timepoint: 6-Minute Walk Test. Method of measurement: Weight in kilograms divided by the square of height in meters. TARBIAT MODARES UNIVERSITY OF TEHRAN Approved 2022-08-27 کارگروه کمیته اخلاق در پژوهش دانشگاه تربیت مدرس Jalal ale Ahmad Tehran Tehran Iran (Islamic Republic of)