IRCT20210720051946N5 IRCT 2022-10-06 Shahid Beheshti University of Medical Sciences Evaluation efficacy of probiotics on some inflammatory factors of ICU cases Evaluation of the effect of probiotic administration of interleukins 6 and 10 levels in poisoned patients admitted to ICU of Loghman hospital in 1400 2022-10-23 anticipated 100 Complete https://irct.ir/trial/66000 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization type will be simple randomization. 100 beads of the same shape and size and with black and white colors will be selected. Then these 100 beads are mixed and thrown into a non-transparent bag. When the patient visits, according to the conditions of entering the study, the researcher will remove a bead from the bag, and if the bead is black, the patient will enter the control group, and if the bead is white, the patient will enter the intervention group. This bead will be stored inside another bag. This will be repeated 100 times, Blinding description: People from the research team who are responsible for the selection and randomization of patients will not be included in the other stages of the research, especially the examination of people in terms of dependent variables. Also after consent form approval, neither patients nor their companions were informed about patients group of control and intervention. Also in control group we will use placebo. 3 Intoxication. Intervention 1: Control group: For seven days, TDS received placebo. Intervention 2: Intervention group: For seven days TDS received two probiotic capsules as gavage. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.