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IRCT20180922041084N8 IRCT 2022-10-11 Shiraz University of Medical Sciences The effect of retrograde autologous priming on anion gap of blood transfusion and glomerular filtration rate in coronary artery bypass grafting The effect of retrograde autologous priming on anion gap of blood transfusion and glomerular filtration rate in coronary artery bypass grafting 2022-11-21 anticipated 140 Complete https://irct.ir/trial/66149 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will use the limited randomization method of the block randomization type. The size of all the blocks is the same. In this experiment, with a sample size of 140, we will have two groups of 70 blocks (including 35 blocks with a size of 4). The randomization list is also taken from the random sequence generation site www.sealedenvelope.com, which can generate a random sequence using the blocking method. The allocation ratio of the samples will be one to one and placed in two intervention groups 1 and the control group. Then, based on the obtained blocks and in the order of the allocation sequence, the necessary technology will be given to the patients. This study is double-blind, Blinding description: This study is double-blind, so that the patient and the personnel collecting information are unaware of the type of intervention in these patients. N/A Coronary heart disease. Intervention 1: Intervention group1: Under general anesthesia, after skin preparation and surgical sterilization, with a median sternotomy approach and heart and lung cannulation, and after injecting 400 units/kg of heparin, they are connected to the cardiopulmonary pump. In group 1, we replace 500 ml of prime solution with 500 ml of the patient's blood in a retrograde manner. Intervention 2: Control group: For the patients in the control group, the standard method is used, in this method, after priming the oxygenator in the usual way, using 1500 ml of Ringer's solution, pulseless blood flow with a flow of 2-2.4 liters per minute per meter square) starts with a moderate decrease in temperature (32-34 centigrade). First, we start the pump slowly and then we remove the clamp on the Venus cannula so that the venous blood enters the oxygenator and then we increase the flow rate to normal. No - There is not a plan to make this available Justification or reason for not sharing IPD is It is against the policies of our center.
public Seyedeh Toktam Seyedhoseyni
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7193711351 +98 71 3647 4270 toktam.seyedhoseyni@gmail.com Shiraz University of Medical Sciences scientific Reza Joybarr
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7193711351 +98 71 3647 4270 joybarr@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Informed consent Patients 45 to 80 years old Candidate patients for coronary artery surgery 45 years 80 years Both Patients with physical conditions higher than grade 3, based on the classification of the American Society of Anesthesiologists(ASA>3) Acute infection Steroid users Vascular problems Non-sinusoidal rhythm Complete branch block Myocardial infarction Recent third-degree block (in the last month) Severe pulmonary disease (based on the doctor's opinion and the use of pulmonary drugs) Kidney disorders (creatinine more than 1.5) Hematocrit less than 30% Discharge fraction less than 40% I25.118 Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris Treatment - Surgery Treatment - Surgery Intervention group1: Under general anesthesia, after skin preparation and surgical sterilization, with a median sternotomy approach and heart and lung cannulation, and after injecting 400 units/kg of heparin, they are connected to the cardiopulmonary pump. In group 1, we replace 500 ml of prime solution with 500 ml of the patient's blood in a retrograde manner. Control group: For the patients in the control group, the standard method is used, in this method, after priming the oxygenator in the usual way, using 1500 ml of Ringer's solution, pulseless blood flow with a flow of 2-2.4 liters per minute per meter square) starts with a moderate decrease in temperature (32-34 centigrade). First, we start the pump slowly and then we remove the clamp on the Venus cannula so that the venous blood enters the oxygenator and then we increase the flow rate to normal. Atrial Fibrillation. Timepoint: The patient's ECG is evaluated before - during - after the opening of the aortic clamp and the start of heart contraction until the last day of the patient's hospitalization in the ICU. Method of measurement: Through ECG monitoring. Shiraz University of Medical Sciences Approved 2022-08-14 "Ethics Committee" of Shiraz University of Medical Sciences 7th floor, research assistant of Shiraz University of Medical Sciences, central building of Shiraz University of Medical Sciences, Zand St. Shiraz Fars Iran (Islamic Republic of)