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IRCT20151123025202N24 IRCT 2022-10-24 Hamedan University of Medical Sciences Effect of oral curcumin on reducing the recurrence of nasal polyposis Evaluation of the effect of oral curcumin on reducing the recurrence of nasal polyposis in patients undergoing endoscopic sinus surgery 2022-11-22 anticipated 36 Complete https://irct.ir/trial/66362 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 36 cards are prepared and on 18 cards the letter C means curcumin and on the other 18 the letter P means placebo is written and each one is put inside an envelope with aluminum foil and the lid is glued and placed inside a box. At the time of patients' arrival, one of the envelopes will be randomly selected and opened. According to the selected letter (C or P) inside the envelope, the patient will be assigned to the curcumin or placebo group, Blinding description: Capsules containing cocumine and placebo will be prepared with the same packaging. The contents of the packages are marked with a code, and the patient and the person evaluating the outcome of the treatment will be unaware of the type of intervention. 3 nasal polyposis. Intervention 1: Intervention group: Patients with chronic sinusitis resistant to treatment after endoscopic sinus surgery, in addition to routine post-treatment care and follow-up, take a 500 mg curcumin capsule daily for 2 months prepared at Hamedan Pharmacy School. Intervention 2: Control group: Intervention group: Patients with chronic sinusitis resistant to treatment after endoscopic sinus surgery, in addition to routine post-treatment care and follow-up, take a capsule containing starch (placebo) daily for 2 months prepared at Hamedan Pharmacy School. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Abbas Moradi
Hamadan, Shahid Fahmideh Avenue, Medical School, Department of Social Medicine
Hamadan Iran (Islamic Republic of) 6517838736 +98 81 3838 0557 a.moradi@umsha.ac.ir Medical Schol scientific Javaneh Jahanshahi
Hamadan, Shahid Fahmideh Avenue, Medical School, Department of ENT
Hamadan Iran (Islamic Republic of) 6517838736 +98 81 3838 0557 jahanshahi@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Patients with chronic sinusitis resistant to drug treatment Having nasal polyps 18 years 60 years Both Having an allergy to turmeric Immunodeficiency problem Suffering from systemic diseases such as diabetes, renal failure, malignancies, cystic fibrosis and granulomatous diseases. J33 Nasal polyp Treatment - Drugs Treatment - Drugs Intervention group: Patients with chronic sinusitis resistant to treatment after endoscopic sinus surgery, in addition to routine post-treatment care and follow-up, take a 500 mg curcumin capsule daily for 2 months prepared at Hamedan Pharmacy School. Control group: Intervention group: Patients with chronic sinusitis resistant to treatment after endoscopic sinus surgery, in addition to routine post-treatment care and follow-up, take a capsule containing starch (placebo) daily for 2 months prepared at Hamedan Pharmacy School. Relapse of polype. Timepoint: Before treatment, 1 month, 4 months and 6 months after treatment. Method of measurement: Nasal endoscopy. Treatment Complication. Timepoint: 1, 2 and 6 months after treatment. Method of measurement: Visual Analogue Score (VAS). Hamedan University of Medical Sciences Approved 2022-09-10 Ethics committee of Hamadan Univercity of Medical Science Hamadan Univercity of Medical Science, Shahid fahmideh Ave, Hamadan Hamadan Hamadan Iran (Islamic Republic of)