]>
IRCT20221016056198N1 IRCT 2022-11-22 Shahid Beheshti University of Medical Sciences evaluation the effect of Alnavar drug on patients with low ovarian reserve in ivf cycle Comparision of corifollitropin alfa versus recombinant FSH in poor ovarian responders 2022-10-19 anticipated 90 Complete https://irct.ir/trial/66385 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: In reproduction and infertility, poor response to ovarian stimulation is one of the important problems and challenges of Bronchis, which causes additional costs, multiple cycles, discouragement and hopelessness in patients, and despite the use of different treatment regimens to manage this special group of patients, there is no single protocol. Corivolitropin alfa (CFA) is a long-acting gonadotropin designed as a stable follicular stimulator with the ability to simplify ovarian stimulation, given that one subcutaneous injection can replace the first seven injections of each cycle. follicle stimulating hormone (FSH). This is especially important considering the psychological discomfort and despair and the high rate of abandonment of continuing IVF treatment in these patients, Randomization description: Patients with previous poor response in ivf cycles will be divided into two groups receiving corifollitropin alpha and recombinant FSH, which will be assigned to one of the two treatment methods based on randomization with replacement blocks with random EXCEL software. All patients will be informed about the study method and cost before entering the study. The advantages and disadvantages of the performed treatment will be informed and an informed consent form will be obtained. 3 diminished ovarian reserve in IVF cycle. Intervention 1: Intervention group that recieved corifolitropin alfa(Elonva),100 microgeram,start at 2th day of mense,Behestan daroo factory. Intervention 2: Control group that recieved recombinant FSH,follitropin alfa,cinnal f,150 mg,cinnagen drug factory. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is i don t decide
public Nazanin Hajizadeh
Velenjak
Tehran Iran (Islamic Republic of) 1985717413 +98 21 2243 2600 hajizadeh.nazanin94@yahoo.com Shahid Beheshti University of Medical Sciences scientific Nazanin Hajizadeh
Velenjak
Tehran Iran (Islamic Republic of) 1985717413 +98 21 2246 3400 hajizadeh.nazanin94@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with hystory of previous cycle ; that who fulfilled at least two of the following criteria were admitted: Antral follicle count (AFC) < 5;Antimullerian hormone (AMH) < 1,1 ng/ml;Less than three oocytes obtained in the previous cycle; 18 years 40 years Female uterine abnormalities, recent or current history of any current untreated endocrine abnormality, unilateral or bilateral hydrosalpinx contraindications for the use of gonadotropins N97.8 Female infertility of other origin Treatment - Drugs Treatment - Drugs Intervention group that recieved corifolitropin alfa(Elonva),100 microgeram,start at 2th day of mense,Behestan daroo factory Control group that recieved recombinant FSH,follitropin alfa,cinnal f,150 mg,cinnagen drug factory The rate of continuous pregnancy is defined despite the intrauterine gestational sac with a fetal pole that shows cardiac activity during the 9th to 10th week of pregnancy. Timepoint: 9-10week after embryo transfer. Method of measurement: trans vaginal sonography. Clinical pregnancy rate, which is defined as the presence of an intrauterine gestational sac in the 7th week of pregnancy. Timepoint: 7week after embryo transfer. Method of measurement: trans vaginal sonography. Implantation rate per number of transferred embryos. Timepoint: 3-5 weeks after embryo transfer. Method of measurement: trans vaginal sonography. Shahid Beheshti University of Medical Sciences Approved 2022-11-13 Ethic committe of Shahid Beheshti University of Medical Sciences Velenjak.shahid arabi street Tehran Tehran Iran (Islamic Republic of)