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IRCT20161207031288N14 IRCT 2022-11-26 Tehran University of Medical Sciences Efficacy and safety evaluation of the cream including Citystem extract and Phytessence extract on reducing skin damage caused by air pollution Efficacy and safety evaluation of the cream including Citystem extract derived from Marrubium vulgare plant and Phytessence extract derived from Phytessence peach flower on reducing skin damage caused by air pollution 2022-11-21 anticipated 26 Complete https://irct.ir/trial/66726 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Balance Blocked Randomization in size 4. An online site (https://www.sealedenvelope.com) will be used to generate a randomized list of study groups. According to the random block method and considering the four blocks, 7 blocks will be produced for 26 patients. Finally, 2 samples are removed to reach 26 patients, Blinding description: Center researchers and participants will be unaware of the study sequence. After confirming new participant to the study and registering the participant code, the study coordinator who is located on the participant recruitment site. Based on the specified randomized sequence and places the participant into treatment groups. and provides them with the drugs that have been tagged with the specific code of each participant. 3 Skin damage caused by air pollution. Intervention 1: Intervention group:Using twice a day (morning and night) the cream containing Citystem extract derived from Marrubium vulgare plant and Phytessence extract derived from Phytessence peach flower plant protects the skin for 8 weeks. Intervention 2: Control group:Using a placebo cream twice a day with the same smell, color and shape as the cream of the intervention group for 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Saman Ahmad Nasrollahi
415, Taleghani St.,Naderi St.
Tehran Iran (Islamic Republic of) 1416613675 +98 21 8897 2220 samannasrol@gmail.com Tehran University of Medical Sciences scientific Alireza Firooz
415, Taleghani St.,Naderi St.
Tehran Iran (Islamic Republic of) 1416613675 +98 21 8897 2220 firozali@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Signing the infirmed consent form and agree to regularly attend follow-up courses 18 -50 years old men and women Exposure to the outside air (at least one hour in a day) 18 years 50 years Both People with any kind of skin disease Suffering from a chronic disease affecting the skin condition (diabetes, thyroid diseases,...) Smoking Pregnancy or lactation Treatment - Drugs Placebo Intervention group:Using twice a day (morning and night) the cream containing Citystem extract derived from Marrubium vulgare plant and Phytessence extract derived from Phytessence peach flower plant protects the skin for 8 weeks Control group:Using a placebo cream twice a day with the same smell, color and shape as the cream of the intervention group for 4 weeks Trance epidermal water lost (TEWL). Timepoint: Before the study, 4 and 8 weeks after the intervention. Method of measurement: MPA 580(Multi Probe Adaptor) device. Skin PH. Timepoint: Before the study, 4 and 8 weeks after the intervention. Method of measurement: MPA 580(Multi Probe Adaptor) device. Skin erythema. Timepoint: Before the study, 4 and 8 weeks after the intervention. Method of measurement: MPA 580(Multi Probe Adaptor) device. Tehran University of Medical Sciences Approved 2021-11-29 Ethics committee of The Institute of Pharmaceutical Sciences of Tehran University of Medical Science Unit 1-219, 2nd floor,The Institute of Pharmaceutical Sciences, Faculty of Pharmacy,16 Azar Avenue Tehran Tehran Iran (Islamic Republic of)