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IRCT20190417043295N3 IRCT 2023-01-03 Ahvaz University of Medical Sciences Comparison of dexmedetomidine and ketamine in serratus anterior plane block in pain control after thoracotomy Comparison of dexmedetomidine and ketamine in serratus anterior plate block in pain control of patients after thoracotomy surgery. A randomized clinical trial study 2022-12-11 anticipated 74 Complete https://irct.ir/trial/66751 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Thoracotomy operations are usually performed within several months of sampling, and the required 74 patients will not undergo such an operation in the hospital at the same time. 74 sealed envelopes with cards inside that include 37 cards number 1 and 37 cards number 2 are prepared and each patient is randomly selected for the group in which they will be studied. Description of groups: 1-Prescription of ropivacaine and dexmedetomidine 2- Prescription of ropivacaine and ketamine. 4 Pain control of patients after thoracotomy surgery. Intervention 1: First, the patient is placed in the supine or lateral decubitus position and a high-frequency linear transducer is used sagittally or transversely on the midaxillary line. The transducer is slowly directed towards the back of the body to reveal the space between the latissimus dorsi and serratus anterior muscles, ribs and pleura. After prep and drape, the needle (22 gauge model Dr. J-602 made by Dr. Japan) is used (in-plane or out of plane). After aspiration, half of the surface solution is injected into the serratus anterior muscle in the depth of the latissimus dorsi muscle and the rest (the other half) in the depth of the serratus anterior muscle, and after the needle is removed, it is placed under pressure and an ice pack. In the first group, ketamine 0.5 mg/kg and 0.4 cc/kg ropivacaine 0.25% and in the second group, in addition to 0.4 cc/kg ropivacaine 0.25%, dexmedetomidine 0.5 macrogram/kilogram was added. Intervention 2: The second intervention group: the second group, dexmedtomidine 0.5 mcg/kg and 0.4 cc/kg rupivacaine 0.25%. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Still undecided - no release schedule yet
public Mahbobeh Rashidi
24 metery street, East sahely highway, Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 0612222922 rashidi-m@ajums.ac.ir Ahvaz University of Medical Sciences scientific Mahbobeh Rashidi
24 metery street, East sahely highway, Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 0612222922 rashidi-m@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Physical condition with ASA class 1 and 2 Age 18 to 60 years 18 years 60 years Both Dissatisfaction to attend the study Injection site infection Allergy to local anesthetic BMI above 40 History of drug or alcohol abuse Pregnancy or breastfeeding History of coagulation problems or use of anticoagulants History of HF and heart conduction disorders (except 1th degree block) and AF Suffering from hepatorenal diseases History of neuropsychological diseases Treatment - Drugs Treatment - Drugs First, the patient is placed in the supine or lateral decubitus position and a high-frequency linear transducer is used sagittally or transversely on the midaxillary line. The transducer is slowly directed towards the back of the body to reveal the space between the latissimus dorsi and serratus anterior muscles, ribs and pleura. After prep and drape, the needle (22 gauge model Dr. J-602 made by Dr. Japan) is used (in-plane or out of plane). After aspiration, half of the surface solution is injected into the serratus anterior muscle in the depth of the latissimus dorsi muscle and the rest (the other half) in the depth of the serratus anterior muscle, and after the needle is removed, it is placed under pressure and an ice pack. In the first group, ketamine 0.5 mg/kg and 0.4 cc/kg ropivacaine 0.25% and in the second group, in addition to 0.4 cc/kg ropivacaine 0.25%, dexmedetomidine 0.5 macrogram/kilogram was added. The second intervention group: the second group, dexmedtomidine 0.5 mcg/kg and 0.4 cc/kg rupivacaine 0.25% Verbal Analog Scale (VAS). Timepoint: This criterion is rated as a continuous line, which is divided from 0-10 into equal intervals before inversion, one hour, six hours, twelve hours, twenty-four hours, and forty-eight hours later, and the patient uses it to reduce pain. He grades himself. Method of measurement: Based on the patient's self-rating of pain intensity. O2 Saturation. Timepoint: Before intervention , one hour, six hours, twelve hours, twenty four hours and forty eight. Method of measurement: Based on measurement with pulse oximetry. Mean arterial pressure. Timepoint: Based on measurement. Method of measurement: mmHg. Heart beat. Timepoint: Based on measurement. Method of measurement: this The information includes body temperature, blood pressure, heart rate, breathing rate, as well as blood oxygen saturation and amount CO2 is the end of exhalation. Patient's pain using verbal pain index (Verbal Analog Scale); that It is a subjective criterion for evaluating pain in patients and is widely used in medical studies. Duration of surgery. Timepoint: Based on measurement. Method of measurement: The duration of the surgery is recorded at the end of the surgery and transferred to the patient's checklist. Ahvaz University of Medical Sciences Approved 2022-11-01 Ethics Committee in Golestan Hospital Research Iran,Golestan Ave, Golestan Hospital Ahvaz Khouzestan Iran (Islamic Republic of)