]>
IRCT20170809035597N3 IRCT 2022-11-19 Iran University of Medical Sciences The effect of topical cyclosporine in lichen planus of the hair Comparison of the efficacy of topical cyclosporine versus clobetasol lotion in patients with lichen planopilaris (LPP) treated with hydroxychloroquine: a single-blinded randomized clinical trial 2022-11-26 anticipated 18 Complete https://irct.ir/trial/66881 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After being selected by available method, patients are divided into two groups by simple randomization, so that among 18 sealed bags, one bag will be randomly selected for each patient. Each bag contains the letter a or b: a for topical cyclosporine and b for clobetasol lotion, Blinding description: The physician who evaluates the severity of the disease and compares the clinical and dermoscopic images, as well as the statistical expert, do not know to which treatment group the patient belongs. 2-3 lichen planopilaris. Intervention 1: Intervention group 1: Topical cyclosporine 2.5% once a day for 5 months. Intervention 2: Intervention group 2: clobetasol lotion 0.05% once a day for 5 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Azadeh Goodarzi
Dermatology ward, Rasool Akram hospital, Niayesh avenue, Satarkhan street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6651 7341 goodarzi.a@iums.ac.ir Iran University of Medical Sciences scientific Afsaneh Sadeghzadeh bazargan
Dermatology ward, Rasool Akram hospital, Niayesh avenue, Satarkhan street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6651 7341 afsaneh.sadeghzadeh@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) patients between 13 and 60 years of age histopathologic diagnosis of lichen planopilaris 13 years 60 years Both Topical or oral treatment in the last month The presence of serious concomitant diseases such as uncontrolled diabetes, uncontrolled hypertension, malignancies, retinal diseases L66.1 Lichen planopilaris Treatment - Drugs Treatment - Drugs Intervention group 1: Topical cyclosporine 2.5% once a day for 5 months Intervention group 2: clobetasol lotion 0.05% once a day for 5 months Disease severity. Timepoint: One, three, five and six months after the start of treatment. Method of measurement: based on LPPAI (lichen planopilaris activity index) criteria. Physician satisfaction. Timepoint: One, three, five and six months after the start of treatment. Method of measurement: Based on the 5-point physician global assessment score using clinical and dermatoscopic images. Patient satisfaction. Timepoint: One, three, five and six months after the start of treatment. Method of measurement: Based on the 5-point patient global assessment score. Tolerability. Timepoint: One, three, five and six months after the start of treatment. Method of measurement: Using a checklist (yes, no). Adverse effects. Timepoint: One, three, five and six months after the start of treatment. Method of measurement: Using a checklist. Iran University of Medical Sciences Approved 2021-09-19 Ethics committee of Iran University of Medical Sciences Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)