IRCT20190901044666N2 IRCT 2022-12-05 Iran University of Medical Sciences The effect of cyclosporine cream on rosacea Evaluation of the efficacy of cyclosporine cream 5% compared to metronidazole gel 0/75% in the treatment of rosacea: A randomized controlled clinical trial 2022-11-26 anticipated 60 Complete https://irct.ir/trial/66894 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After being selected by available method, patients are divided into two groups by simple randomization, so that among 60 sealed bags, one bag will be randomly selected for each patient. Each bag contains the letter a or b: a for metronidazole gel and b for cyclosporine cream, Blinding description: The evaluation of the study results is performed by an evaluator blinded to the type of intervention (a dermatologist who does not know which treatment group the patient belongs to) and based on the images of the lesions taken in each session. Data analysis is also performed by a blinded statistician. 2-3 Erythematotelangiectatic or papulopustular rosacea. Intervention 1: Intervention group 1: Treatment with metronidazole gel 0.75% once per night for 3 months. For this purpose, the patient uses a thin layer of metronidazole gel locally on his/her erythematotelangiectatic or papulopustular lesions. Intervention 2: Intervention group 2: Treatment with cyclosporine cream 5% once a night for 3 months. For this purpose, the patient uses a thin layer of cyclosporine cream locally on his/her erythematotelangiectatic or papulopustular lesions. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information