IRCT20211101052940N2 IRCT 2023-04-14 Shahid Rajaei Cardiovascular Hospital The effect of moderate acidification of arterial blood pH on the rate of miR-499 Biomarker level in the early minutesafter aortic clamp opening during heart valve surgery: A Pilot Study The effect of moderate acidification of arterial blood pH on the rate of miR-499 Biomarker level in the early minutes after aortic clamp opening during heart valve surgery: A Pilot Study 2022-12-01 anticipated 60 Complete https://irct.ir/trial/66918 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The patients were divided into 2 groups of 30 people using the computer program CREATE A RANDOMISATION LIST, in the form of block randomization with a size of 4. Thus, 15 blocks of 4 were obtained, and in each block, 2 patients were randomly assigned to the intervention group and 2 patients to the control group. In each block, the permutations created were in the form of AABB, ABAB, ABBA, BBAA, ... where each A was the sign of the intervention group and the letter B was the sign of the control group, Blinding description: In this study, the intensive care unit nurse who is responsible for caring for the patient is kept blind. N/A The effect of moderate arterial blood acidosis during reperfusion in valvular heart surgery. Intervention 1: Intervention group: Temporary respiratory acidosis is induced for the reperfusion phase by intentional inhalation of Carbon dioxide gas into the oxygenator, and therapeutic hypercapnia (partial pressure of carbon dioxide = 50-60) is performed to establish a pH in the range of 7.25 to 7.30. In contrast, 5 minutes before reperfusion, gas is added to the mixture of oxygen and air, and after opening the aortic clamp, it continues for 2 minutes after reperfusion. Intervention 2: Control group: In the control group, blood re-perfusion to the heart is performed after opening the aortic clamp, with a pH in the normal range, i.e. 7.35 to 7.45. No - There is not a plan to make this available Justification or reason for not sharing IPD is Based on the consent obtained from patients, their information remains confidential.