IRCT20221111056474N1 IRCT 2022-12-09 Arak University of Medical Sciences Comparison of the effects of ketamine and paracetamol on nausea and vomiting after hysterectomy Comparing the effect of intravenous combined Paracetamol (Apotel) and Ketamine on postoperative nausea and vomiting in patients candidating hysterectomy 2022-12-22 anticipated 114 Complete https://irct.ir/trial/67025 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be assigned to two intervention groups and one control group based on the randomization sequence that will be generated in advance, in the order of arrival, and this sequence is unpredictable and its arrangement is completely random. To allocate the samples, the block randomization method will be used with the size of 3 and 6 blocks in such a way that by using the Sealed Envelope software to generate random numbers in the block method, the randomization sequence will be produced according to the required sample size for the three groups. In the beginning, all the modes in which 3 letters A, B and C can be arranged together in blocks of 3 and 6 are produced and randomly and by placing among the blocks, a block is selected and the pattern of arrangement in that block is for allocation. Patients will be used, then this block will be placed in the main container and another block will be selected again. 3 and 6 blocks will all be in one container, Blinding description: This study is double blind. To observe the blinding of the first type, the patients do not know the type of medicine received. In all three groups, the same syringes are used, and the patient and the person in charge of the project do not know about their contents. In order to observe the blinding of the second type, the injection drugs were drawn in separate syringes by the respected anesthetist, and the person in charge of the project (a student) was drawn from the contents. It has no information. 3 Nausea and vomiting after hysterectomy. Intervention 1: Intervention group 1: After induction of anesthesia in all patients, in the first intervention group, in the last 15 minutes of the operation, an amount of one gram of Apotel (Kobel Daru-Iran) is injected as a slow intravenous injection. Intervention 2: Intervention group 2: After induction of anesthesia in all patients, in the second intervention group, ketamine (Darman yab -Iran) is injected intravenously at a rate of 0.15 mg/kg in the last 15 minutes of the operation. Intervention 3: Control group: After induction of anesthesia in all patients, in the control group, 30 cc of normal saline is slowly injected intravenously in the last 15 minutes of the operation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.