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IRCT20221127056629N1 IRCT 2022-12-18 sirjan school of medical science The effect of licorice administration on patients with rheumatoid arthritis The effects of licorice supplementation on clinical symptoms and inflammatory markers in patients with active rheumatoid arthritis 2022-12-22 anticipated 76 Complete https://irct.ir/trial/67082 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into two groups of intervention (38 patients) and placebo (38 patients). Supplement and placebo will be placed in similar containers by someone outside the study based on the corresponding codes written on the containers. Supplement or placebo recipients will be assigned based on entry code. In this double-blind study, the factors that can distort the results of the experiment, such as information about receiving a supplement or placebo, will remain hidden from both the participants (patients) and the researcher, Blinding description: Supplement and placebo will be placed in similar containers by someone outside the study based on the corresponding codes written on the containers. Supplement or placebo recipients will be assigned based on entry code. In this double-blind study, the factors that can distort the results of the experiment, such as information about receiving a supplement or a placebo, will remain hidden from both the participants (patients) and the researcher. 2-3 Rheumatoid Arthritis. Intervention 1: Intervention group: Rheumatoid arthritis patients who received capsules containing 0.5 mg of licorice prepared by Iran Daruk Company 3 times a day for 8 weeks. Intervention 2: Control group: Rheumatoid arthritis patients receiving capsules containing placebo, prepared by Iran Daruk Company, receive orally 3 times a day for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Mohammad amin serpoosh
ibn sina street , sirjan school of medical sicence
sirjan Iran (Islamic Republic of) 7816916338 +98 34 4223 4513 aminsrps@gmail.com sirjan school of medical science scientific Dr mahmood reza masoudi
ibn sina street sirjan school of medical science
sirjan Iran (Islamic Republic of) 7816916338 +98 34 4223 4513 Masoodi85@yahoo.com sirjan school of medical science Iran (Islamic Republic of) Patients with joint rheumatism referring to Sirjan Faculty of Medical Sciences clinic Filling the consent form by patients 20 years 70 years Both Heart, kidney or hypertension patients, history of heart attack, high blood lipids, abnormal kidney or liver function, use of non-steroidal anti-inflammatory drugs, use of vitamins and/or mineral supplements and drugs such as thyroid hormones, anti-hypertensive drugs Blood, contraceptives, diuretics and beta-blockers, as well as alcohol consumption, smoking, pregnancy and breastfeeding Other underlying diseases and also it should be mentioned that each person participating in the study will be excluded from the study in case of discontinuation of treatment or side effects caused by the consumption of licorice. M05 Rheumatoid arthritis with rheumatoid factor Treatment - Drugs Placebo Intervention group: Rheumatoid arthritis patients who received capsules containing 0.5 mg of licorice prepared by Iran Daruk Company 3 times a day for 8 weeks. Control group: Rheumatoid arthritis patients receiving capsules containing placebo, prepared by Iran Daruk Company, receive orally 3 times a day for 8 weeks. Disease severity. Timepoint: 0،90. Method of measurement: Disease activity score 28 ( DAS28). Erythrocyte sedهmentation rate. Timepoint: 0،90. Method of measurement: Westergren method. Intensity of pain. Timepoint: 0،90. Method of measurement: The patients will be asked to mark their pain level from their point of view on a ten-point scale. CRP. Timepoint: 0,90. Method of measurement: Agglutination method. TNF-α. Timepoint: 0,90. Method of measurement: Eliza method. IL-6. Timepoint: 0,90. Method of measurement: Eliza method. Systolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer. Diastolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer. AST. Timepoint: 0,90. Method of measurement: Colorimetric method and photometer. Licorice. Timepoint: 0,90. Method of measurement: by scales. Potassium. Timepoint: 0,90. Method of measurement: Flynn photometry method. Fasting blood sugar. Timepoint: 0،90. Method of measurement: Colorimetric method and photometer. sirjan school of medical science Approved 2022-11-19 کمیته اخلاق دانشکده علوم پزشکی سیرجان Ibn Sina St., Sirjan school of Medical Sciences sirjan Kerman Iran (Islamic Republic of)