IRCT20221127056624N1 IRCT 2022-12-04 Babol University of Medical Sciences The effect of preoperative antibiotic prophylaxis in ureteral stone crushing surgery Effect of prophylactic antibiotics before intraureteral lithotripsy on infection and inflammatory factors 2022-12-15 anticipated 80 Complete https://irct.ir/trial/67085 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: After applying the entry and exit criteria, subjects will be randomly assigned using permutation blocks. By using Sealedenvelop.com software, a sequence of size 80 will be produced. The randomization unit is an individual. The size of the blocks is 4 and in each block each intervention group will be repeated twice (the randomization ratio in each block is 1:1). Using this randomly generated list, the participants are assigned to one of the two study groups. In order to hide the list of random allocation, a special code will be assigned to each of the intervention groups, which even the main implementer of the project (supervisor) is not aware of. These codes are written on a paper and placed inside a sealed envelope. A unique code specific to each patient will be written on this paper and its envelope. All envelopes will be placed in a larger box in random order and sealed in the box. The main researcher, after reviewing the criteria for entering the study and obtaining informed consent, as well as registering the patient's profile in a special form, in collaboration with the random allocation list (this person is an expert, other than the main researcher, who is involved in the patient recruitment process and sample entry) is called and randomization of that patient is done, Blinding description: After selection and randomization, patients will be divided into groups a and b. The form of the drugs is completely the same, so the patient will not know the type of intervention. The participants and those who will assess the outcome will not know how the patients are arranged in the groups. Therefore, the study will be conducted in a double-blind manner. 2 Ureteral stone. Intervention 1: Intervention group: Intravenous antibiotic cefazolin with a dose of 1 gram (obtained from Aria Pharmaceutical Company) will be given intravenously half to one hour before the operation and two doses (1 gram) after the operation at an interval of 6 hours. Intervention 2: Control group: They will receive 10 cc of normal isotonic saline (placebo) half to an hour before the operation and two doses after the operation at an interval of 6 hours, intravenously. The placebo will be designed to look similar to cefazolin. No - There is not a plan to make this available Justification or reason for not sharing IPD is .