IRCT20211108053007N1 IRCT 2023-02-14 Shahid Beheshti University of Medical Sciences The effects of synbiotic supplement containing Bacillus coagulans and fructooligosaccharide on Quality of life (physical and mental health status) in women with polycystic ovarian syndrome. The effects of synbiotic supplement containing Bacillus coagulans and fructooligosaccharide on Quality of life (physical and mental health status) in women with polycystic ovarian syndrome. 2023-02-19 anticipated 30 Complete https://irct.ir/trial/67104 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to randomly assign women, stratified block randomization method is used based on BMI, the use of hormonal drugs that regulate the menstrual cycle, and metformin, Blinding description: Placebo sachets are completely similar in appearance to synbiotic sachets. In order to carry out this research in a three-blind manner, at the time of the start of the study, the set of sachets containing synbiotic or placebo supplements are coded as A and B by the factory so that the researcher, statistical analyst and patients are not informed about the type of supplements received by each group. 3 Polycystic Ovary Syndrome. Intervention 1: Intervention group: For 12 weeks, they will receive daily one 2 gram sachet of synbiotic containing 10 to the power of 11 CFU/g of Bacillus coagulans, 10 to the power of 10 CFU/g Lactobacillus rhamnus, 10 to the power of 10 CFU/g Lactobacillus heloticus, 500 mg fructo-oligosaccharide and 0.7% orange flavor. Intervention 2: Control group: They will receive a placebo sachet daily containing 2 grams of starch and 0.7% orange flavoring. Yes - There is a plan to make this available What will be shared: Only part of the data, such as the main results, will be shared. When: The beginning of the access period is 12 months after the publication of the results To whom: It will be available for researchers working in academic and scientific institutions and industry. Conditions: The documentation can only be used for more complete studies in this field. Where to obtain: Zahra Hariri How to obtain: Communication will be possible through the email given in the previous section Comments: