]>
IRCT20221026056307N1 IRCT 2023-01-18 Bojnourd University of Medical Sciences Investigating the effectiveness of anticoagulants compared to aspirin and clopidogrel on disease severity in patients with ischemic stroke. Investigating the effectiveness of anticoagulants compared to aspirin and clopidogrel on disease severity in patients with ischemic stroke. 2023-02-20 anticipated 86 Complete https://irct.ir/trial/67255 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: In this study, due to the fact that two tablets (aspirin and clopidogrel) will be used in one group and one tablet and one ampoule (rivaroxaban and enoxaparin) will be used in the other group, complete blinding is not possible. Because the researchers do not want to use additional and unnecessary injections for blinding. For this purpose, a research assistant (for example, a neurology department nurse) who is not blind will be used to prescribe drugs. But the treating doctor and the analyst will not be aware of the drugs received by the patient. 3 Cerebral infarction. Intervention 1: Intervention group: An enoxaparin group with a therapeutic dose (one mg per body weight) is prescribed in the first 24 hours and then on the second day of starting rivaroxaban with a dose of 20 mg along with enoxaparin 40 mg daily from the beginning and will receive it for 10 days. Intervention 2: Intervention group: The other group will receive aspirin 80 mg and clopidogrel 75 mg from the beginning and will receive it for 10 days. Yes - There is a plan to make this available What will be shared: The data is expected to be published in 2023 When: The data is expected to be published in 2023 To whom: public Conditions: Research projects have been developed Where to obtain: Dr.Amirali Ghahramani How to obtain: Application from North Khorasan University of Medical Sciences Comments:
public Amir Ali Ghahramani
Immam Hasan Hospital, Blv.Shohadayeh Arkan, Bojnurd
Bojnurd Iran (Islamic Republic of) 7487794149 +98 58 3151 1421 amirali.ghahremani@yahoo.com Bojnourd University of Medical Sciences scientific Amir Ali Ghahramani
Immam Hasan Hospital, Blv.shohadayeh Arkan, Bojnurd
Bojnurd Iran (Islamic Republic of) 7487794149 009831513001 amirali.ghahremani@yahoo.com Bojnourd University of Medical Sciences Iran (Islamic Republic of) Patients with ischemic stroke without embolic origin Patients aged 18 to 90 years NIHSS less than 15 18 years 90 years Both Patients with hemorrhagic stroke Patients with ischemic stroke of embolic origin Stroke patients with NIHSS scores less than 15 I63 Cerebral infarction Treatment - Drugs Treatment - Drugs Intervention group: An enoxaparin group with a therapeutic dose (one mg per body weight) is prescribed in the first 24 hours and then on the second day of starting rivaroxaban with a dose of 20 mg along with enoxaparin 40 mg daily from the beginning and will receive it for 10 days. Intervention group: The other group will receive aspirin 80 mg and clopidogrel 75 mg from the beginning and will receive it for 10 days. MRS scores. Timepoint: 10 days and 3 months after the intervention. Method of measurement: MRS is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability.A score of 0 is no disability, 5 is disability requiring constant care for all needs; 6 is death. NIHSS scores. Timepoint: 10 days and 3 months after the intervention. Method of measurement: The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment.The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. Bojnourd University of Medical Sciences Approved 2022-08-28 Ethics Committee of North Khorasan University of Medical Sciences Immam Hasan Hospital, Arkan Blvd, Bojnurd, Bojnurd North Khorasan Iran (Islamic Republic of)