IRCT20120415009475N14 IRCT 2023-10-11 Vice Chancellor for research of Shahid Beheshti University of Medical Sciences Olanzapine in pediatric chemotherapy induced nausea and vomiting in Assessing the effectiveness of olanzapine in treating nausea and vomiting caused by chemotherapy in children. 2023-11-22 anticipated 56 Complete https://irct.ir/trial/67340 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization is done based on the block randomization method with non-consequential codes generated by an online tool (sealedenvewlope.com), Blinding description: The medication and placebo will be in look-alike coded packages, and the codes based on the block randomization table will be provided to the researcher by a designated person via phone. At the end of the study, after organizing the data by the same person, the statistical expert will perform the analysis. Then, the code packet will be opened, and the final results will be reported. 3 Chemotherapy induced nausea and vomiting. Intervention 1: Intervention group: Olanzapine dosing 0.1 milligrams per kilogram once daily at bedtime starting with chemotherapy for 3 days. Intervention 2: Control group: Placebo with the same packing once daily at bedtime starting with chemotherapy for 3 dayschemotherapy. Yes - There is a plan to make this available What will be shared: the primary outcome measure only When: starting 6 months after publication To whom: this will be only available to people working in academic institutions. Conditions: Data will be available to be used for meta-analysis and systematic review. Where to obtain: via an academic email to the corresponding author. How to obtain: requesting and reviewing the proposal abstract of the research and academic profile of the researcher (10 working days). Comments: