IRCT20120215009014N450 IRCT 2022-12-19 Hamedan University of Medical Sciences Effect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentation Effect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentation: a double-blind randomized clinical trial 2023-02-20 anticipated 40 Complete https://irct.ir/trial/67397 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the right and left sides of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "right" on one sheet and "left" on another. Then, by referring to every patient, one of the sheets will be randomly taken. According to whether the sheet is taken right or left is assigned to the intervention group and the other side to the control group, Blinding description: The shape of the medications and placebos will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Thus, the trial will be run as double-blind. 3 Postinflammatory hyperpigmentation. Intervention 1: Intervention group: Herbal cream containing pomegranate and saffron extract on the left side of the face twice a day for 12 weeks. Intervention 2: Control group: Cream Azelaic acid 20% on the right side of the face twice a day for 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.