]>
IRCT201104266292N1 IRCT 2011-05-31 Tehran University of Medical Sciences The effect of progesterone supplementation on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles: a randomized prospective trial The effect of progesterone supplementation on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles: a randomized prospective trial 2009-10-23 anticipated 300 Complete https://irct.ir/trial/6741 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Condition 1: Female infertility, unspecified. Condition 2: Male infertility. Intervention 1: Intervention: application of progesterone 400 mg vaginal suppository Cyclogest once daily from the day of IUI until negative beta HCG or 12 week. Intervention 2: Controi: no drug.
public Mahboobeh Rahmani
Gisha Brd Amirabad Ave
Tehran Iran (Islamic Republic of) +98 21 8800 8810 rahmani@razi.tums.ac.ir Tehran University of Medical Science, Shariati Hospital scientific Mahboobeh Rahmani
Gisha Brd, Amirabad Ave
Tehran Iran (Islamic Republic of) +98 21 8800 8810 rahmani@razi.tums.ac.ir Tehran University of Medical Science, Shariati Hospital Iran (Islamic Republic of) Inclusion criteria: All women included in the study were between the age 18 and 35 years and BMI of 18-28 kg/m2, regular mense, and no PCOD (according to Rotterdam criteria), basal FSH<10 IU/L and normal serum prolactin level and normal thyroid function. All couples had been trying unsuccessfully to conceive for at least one year before being enrolled in the trial. All women had bilateral tubal patency and normal uterine cavity, confirmed by hysterosalpinography (HSG), performed a maximum of 6 months before the start the stimulation. Men had at least two semen analyses before any treatment. Normal semen analysis were defined by the threshold values of the World Health Organization criteria, ≥4% sperm had normal morphology according to the criteria of Kruger et al, or total motile sperm count ≥ 1 million following semen preparation Exclusion criteria: abnormal prolactin serum level and abnormal thyroid function test, polycystic ovary syndrome according to Rotterdam criteria, diminished ovarian reserve (basal FSH level >10 IU/mL, presence of resistant ovarian cyst (>20mm for > 1 months), hypogonadotrophic hypogonadism or any contraindications for progesterone therapy 18 years 35 years Female N97.9 N46 inability to achieve a pregnancy Azoospermia NOS Treatment - Drugs Treatment - Drugs Intervention: application of progesterone 400 mg vaginal suppository Cyclogest once daily from the day of IUI until negative beta HCG or 12 week Controi: no drug Clinical pregnancy rate. Timepoint: 4 weeks after insemination. Method of measurement: Transvaginal sonography. Ovulation rate. Timepoint: The days 12, 14 cycles. Method of measurement: Transvaginal sonography. Tehran University of Medical Sciences Approved 2011-05-09 Tehran University of Medical Sciences Keshavarz Blvd, Ghods Street Tehran Iran (Islamic Republic of)