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IRCT20221206056736N1 IRCT 2023-04-17 Shahid Beheshti University of Medical Sciences effect of IPL with and without intradermal injection of tranexamic acid in treatment of post acne Erythema Investigation of the effect of IPL with and without intradermal injection of tranexamic acid in treatment of resistant post acne Erythema , An split face control trial in loghman hakim hospital in 1401 2023-02-04 anticipated 25 Complete https://irct.ir/trial/67423 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Flip the coin, when the coin comes to the heads side , the right side of the face is intervened, and when the coin comes to the tails,the left side of the face is intervened, Blinding description: The patient is unaware of the side of the intervention and examination of treatment response and comparison of two sides of the face by a dermatologist who is unaware of the assignment of the facial area to receive tranexamic acid or placebo. 3 post acne erythema. Intervention 1: Intervention group: On the selected side of the face, ampoules of 500mg/5ml tranexamic acid will be injected intradermally by 1cc syringes at a distance of one centimeter in the areas with erythema caused by acne inflammation in the same session. Intervention 2: Control group: On the other side of the face, normal saline is injected intradermally by 1cc syringes at a distance of one centimeter in areas with erythema caused by acne inflammation in the same session. Yes - There is a plan to make this available What will be shared: All data is shared after de-identifying people's faces and characteristics. Community Verified icon When: Since the publication of the results for one year To whom: Researchers Conditions: In order to evaluate the obtained results, unidentifiable photos of the patients can be accessed. Where to obtain: Go to Nushin Golchin's email address at Nushin.golchin@yahoo.com. How to obtain: Submit the application and submit valid documents, then check the applicant's profile and send the application file if eligible. Community Verified icon Comments:
public Nushin Golchin
No 2,West fahad Allay,Falsafi Ave, Ekbatan town
Tehran Iran (Islamic Republic of) 1393843673 +98 21 4469 7518 Nushin.golchin@yahoo.com Shahid Beheshti University of Medical Sciences scientific Nushin Golchin
No 2,West fahad Allay,Falsafi Ave,Ekbatan town
Tehran Iran (Islamic Republic of) 1393843673 +98 21 4469 7518 Nushin.golchin@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) people with persistent post acne erythema that did not improve for at least 3 months in the age range of 16 to 40 years 16 years 40 years Both coagulation disorders such as DIC ,pulmonary embolism,stroke,DVT suffering from cancers sensitivity to tranexamic acid in previous use consumption of drugs that interfere with the use of tranexamic acid (anticoagulants,estrogenic drugs,tretinoin and anti inhibitory coagulation concentrates ) pregnancy,breastfeeding and the decision to become pregnant oral and topical use of retinoids in the last 6 months prone to keloid formation photosensitivity the use of exfoliating topical drugs including AHA L70.0 Acne vulgaris Treatment - Drugs Placebo Intervention group: On the selected side of the face, ampoules of 500mg/5ml tranexamic acid will be injected intradermally by 1cc syringes at a distance of one centimeter in the areas with erythema caused by acne inflammation in the same session. Control group: On the other side of the face, normal saline is injected intradermally by 1cc syringes at a distance of one centimeter in areas with erythema caused by acne inflammation in the same session. Erythema improvment on the right and left side of the face. Timepoint: The beginning of the study, day 21, day 42, day 72. Method of measurement: Scale of Clinician erythema assessment. Patient satisfaction from treatment on the right and left side compared to before. Timepoint: The beginning of the study, day 21, day 42, day 72. Method of measurement: Asking the patient to choose a number from 1 (low) to 4 (very high) ,from the level of satisfaction with the treatment on each side of face. The side effects. Timepoint: The beginning of the study, day 21, day 42, day 72. Method of measurement: Questions and comparisons. Shahid Beheshti University of Medical Sciences Approved 2022-11-09 Ethics committee of Shahid beheshti University of Medical Sciences Shahid beheshti univerciyt,arabi Ave Tehran Tehran Iran (Islamic Republic of)