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IRCT20190901044666N3 IRCT 2022-12-17 Iran University of Medical Sciences The effect of 5% phenytoin solution in improving androgenic hair loss Formulation, physicochemical characterization and single-group phase II clinical trial with comparison before and after treatment to evaluate the efficacy and clinical safety of 5% phenytoin solution in improving androgenic hair loss 2023-01-21 anticipated 15 Complete https://irct.ir/trial/67437 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Androgenic alopecia. Intervention group: treatment with 5% phenytoin solution twice a day for 4 months. For this purpose, the patient uses one milliliter of 5% phenytoin solution topically on his scalp.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Not clear
public Afsaneh Sadeghzadeh bazargan
Rasool Akram Hospital, Niayesh St, Satarkhan Av, Tehran, Iran
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2421 sadeghzadeh.a@iums.ac.ir Iran University of Medical Sciences scientific Afsaneh Sadeghzadeh bazargan
Rasool Akram Hospital, Niayesh St, Satarkhan Av, Tehran, Iran
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2421 sadeghzadeh.a@iums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) A man aged between 18 and 50 years Hair loss pattern based on Hamilton Norwood scale (II, III, IV) Sign the consent form Enjoying general health 18 years 50 years Male L64 Androgenic alopecia Treatment - Drugs Intervention group: treatment with 5% phenytoin solution twice a day for 4 months. For this purpose, the patient uses one milliliter of 5% phenytoin solution topically on his scalp. The number of hairs in a specified area of the scalp. Timepoint: At screening, 2 and 4 months after treatment. Method of measurement: ترجمه بیش از حد طولانی است و ذخیره نمی‌شودIn this examination, the area of the scalp is determined, and all examinations are performed on that area. The number of hairs at the beginning of the study, 2 months later and 4 months later is counted by the FotoFinder Tricoscale device. The tricoscale program from the FotoFinder device, a new program for documenting and quantifying hair loss, with the help of this software, all the basic parameters of hair growth and loss are calculated automatically. The parameters measured by this device are: calculating the number and density of hairs, the ratio and frequency of anagen and telogen hairs, the number and density of vulus and terminal hairs, determining hair thickness (optional), determining the number of follicular units. At the same time, the condition of the entire head hair is checked by a precision camera at the beginning of the study, 2 and 4 months after the treatment. Iran University of Medical Sciences Approved 2022-12-05 Ethics committee of Iran University of Medical Sciences, School of Medicine School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)