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IRCT20100501003844N5 IRCT 2023-02-15 Rasht University of Medical Sciences The effectiveness of transcranial direct current stimulation on the clinical outcomes of chronic migraine patients Comparison of the effectiveness of transcranial direct current stimulation with three approaches, anodal occipital cortex, cathodic occipital cortex and sham on clinical outcomes in patients with chronic migraine 2023-03-21 anticipated 144 Complete https://irct.ir/trial/67591 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this clinical trial study, 114 patients suffering from chronic migraine and resistant to prescribed drugs, who referred to the pain clinic of Velayat Hospital, were randomly selected using the random block method using blocks of 6 and using From the website https://www.sealedenvelope.com, they will be assigned to three groups A, B, C as follows, with an equal allocation ratio in each group by a person not involved in the research. 1) anodal tDCS of the occipital cortex, anode electrode on the occipital cortex of the dominant side of pain and cathode on the chin, 2) cathodal tDCS of the occipital cortex, cathode electrode on the occipital cortex of the dominant side of pain and anode electrode on the chin of the opposite side, 3) stimulation group fake, Blinding description: To hide the allocation of drugs, they will be placed in a sealed, numbered matte envelope. The preparation of the envelopes and the random sequencing of the allocation will be done by a person not involved in the research. N/A Migraine patients. Intervention 1: Intervention group: Occipital cortex anodal tDCS groupو the anode electrode is placed on the occipital cortex on the dominant side of the pain and the cathode on the chin on the opposite side. Intervention 2: Intervention group: Cathodal tDCS group of the occipital cortex, the cathode electrode is placed on the occipital cortex of the dominant side of the pain and the anode electrode is placed on the chin of the opposite side. Intervention 3: Control group: The fake stimulation group (sham) also has electrodes with the same arrangement (occipital cortex and chin) and for the duration of the experimental group, with the difference that the electric current will be cut off after 30 seconds. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Cyrus Amir Alavi
Velayat Educational and Medical Center, Namjo St.
Rasht Iran (Islamic Republic of) 4193713194 +98 13 3336 8814 cyrusemiralavi@yahoo.com Rasht University of Medical Sciences scientific Cyrus Amir Alavi
Velayat Educational and Medical Center, Namjo St.
Rasht Iran (Islamic Republic of) 4193713194 +98 911 131 7398 Cyrusemiralavi@yahoo.com Rasht University of Medical Sciences Iran (Islamic Republic of) Patients with chronic migraine Resistant to drug treatments Those who experience frequent migraine attacks Experienced at least 4 attacks per month or 8 days of migraine attacks per month 18 years 65 years Both History of neurological diseases History of mental disorder and use of antipsychotic and antidepressant drugs History of treatment with tDCS or other brain stimulation techniques Taking drugs that block voltage-dependent sodium and calcium channels Failure of the patient to continue participating in the study G43 Migraine Treatment - Devices Treatment - Devices Placebo Intervention group: Occipital cortex anodal tDCS groupو the anode electrode is placed on the occipital cortex on the dominant side of the pain and the cathode on the chin on the opposite side. Intervention group: Cathodal tDCS group of the occipital cortex, the cathode electrode is placed on the occipital cortex of the dominant side of the pain and the anode electrode is placed on the chin of the opposite side. Control group: The fake stimulation group (sham) also has electrodes with the same arrangement (occipital cortex and chin) and for the duration of the experimental group, with the difference that the electric current will be cut off after 30 seconds. Number of migraine days per month, pain intensity, frequency of taking painkillers. Timepoint: Before the start of the intervention, after the last session of the intervention and two months after. Method of measurement: Based on questions from the patient. Intensity of pain. Timepoint: Before the start of the intervention, after the last session of the intervention and two months after. Method of measurement: Using Visual Analogue Scale(VAS), according to patient report. Rasht University of Medical Sciences Approved 2022-07-13 Ethics committee of Guilan University of Medical Sciences University Research and Technology Vice-Chancellor- in front of 17 Shahrivar Hospital- Shahid Siadati St. -Namjo St. Rasht Guilan Iran (Islamic Republic of)