IRCT20200127046282N31 IRCT 2023-05-18 Tehran University of Medical Sciences Evaluation of the effect of nanofat along with SVF and PRP in facial rejuvenation and dark circles around the eyes Evaluation of the effectiveness of nanofat along with Stromal vascular fraction (SVF) and Platelet Rich plasma (PRP) in facial rejuvenation and dark circles around the eyes 2023-05-20 anticipated 30 Complete https://irct.ir/trial/67652 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The patient and the doctor will have enough information about the treatment due to the sampling of fat tissue and blood. After transplantation and in the follow-up phase, all participants will be examined by a medical staff who is blinded to this study and group allocation. At this stage, this person does not know the type of intervention in each group. Therefore, the study will be single blind. 1-2 Condition 1: periorbital dark circles. Condition 2: Skin aging. Intervention 1: Control group 1: In one session, patients are treated with 5 cc of nanofat injection (prepared at the research center clinic) in the whole face and under the eyes. Intervention 2: Control group 2: Patients are treated in one session by injecting 5 cc of nanofat (prepared in the research center clinic) and 2 cc of PRP (prepared in the research center laboratory) in the whole face and under the eyes. Intervention 3: Intervention group: In one session, patients were treated by injecting 5 cc of nanofat (prepared in the clinic of the research center), 1 cc of adipose tissue SVF (prepared in the clean room of the research center) and 1 cc of PRP (prepared in the laboratory of the research center) in They are placed on the whole face and under the eyes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.