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IRCT201402116318N3 IRCT 2014-03-19 Semnan University of Medical Sciences Comparing the effectiveness of ophthalmic vitamin A ointment and moisture chamber to prevent ocular surface disorders in critically ill patients Comparing the effectiveness of ophthalmic vitamin A ointment and moisture chamber to prevent ocular surface disorders in critically ill patients 2014-02-21 anticipated 15 Complete https://irct.ir/trial/6770 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Ocular Surface disorders. Intervention 1: After standard eye care (washing the eye and the skin around the eye with five to 10 cc saline), one of the patient' eye were randomized receives a piece of thin layer of transparent polyethylene to cover the eye from the eyebrow to the cheek bone every 12 hour. Anti-allergy adhesive tape was used to secure the edges of the polyethylene cover. Intervention 2: After standard eye care (washing the eyelids and the skin around the eye with five to 10 cc saline), one of the patient' eye were randomized, every 6 hour, about two centimeters the vitamin A ophthalmic ointment are apply into the inferior fornix by the patient' nurse and the eyelid is closed by hand.

public Dr. Monir Nobahar

Semnan, University of Medical Sciences, Nursing and Paramedical University

Semnan Iran (Islamic Republic of) 3513138111 +98 23 1335 4170 Nobahar43@sem-ums.ac.ir Nobahar43@yahoo.com Semnan University of Medical Sciences scientific Dr Monir Nobahar

Semnan, University of Medical Sciences, Nursing and Paramedical University

Semnan Iran (Islamic Republic of) 3513138111 +98 23 1335 4170 Nobahar43@sem-ums.ac.irNobahar43@yahoo.com Semnan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: over 18 years old; corneal health in the initial of examination; hospitalized in intensive care unit at least for three days; conscious degree less than 8 according to Glasgow Coma Scale; inexistence of face or eye trauma; inexistence of eye problems history. Exclusion criteria: Existence of chemosis, eye lid position grade difference in the initial of examination; Bell’s palsy or hemiplegia; also if patient is capable of blinking for three days; corneal disorder at any stage of the test, recorded and the patient excluded from study continuing. 18 years no limit Both H16.8 Other keratitis Other Treatment - Drugs After standard eye care (washing the eye and the skin around the eye with five to 10 cc saline), one of the patient' eye were randomized receives a piece of thin layer of transparent polyethylene to cover the eye from the eyebrow to the cheek bone every 12 hour. Anti-allergy adhesive tape was used to secure the edges of the polyethylene cover. After standard eye care (washing the eyelids and the skin around the eye with five to 10 cc saline), one of the patient' eye were randomized, every 6 hour, about two centimeters the vitamin A ophthalmic ointment are apply into the inferior fornix by the patient' nurse and the eyelid is closed by hand. Ocular surface disorders. Timepoint: In 1th to 5th days. Method of measurement: The assessment tool of ocular surface disorders in this study is including Schirmer and Fluorescein tests. Schirmer test is done one time before the initiation and one time at the end of the study. To do the test Schirmer's graded paper will inserted in inferior fornix of lower eyelid at the junction of the middle third and outer third of the eyelid and the eyelid is closed and after five minutes, the height of the paper moist is measured in millimeters. Fluorescein test done daily till five days. Thus after corneal staining with fluorescein, existence of corneal damage assess by using pen light with blue light (cobalt) and 20 diopter lens and the test result is ranking according to Oxford grading scale. Semnan University of Medical Sciences Approved 2014-03-04 Semnan University of Medical Sciences Semnan, University of Medical Sciences, Nursing and Paramedical University Semnan Iran (Islamic Republic of)