IRCT20221230056983N1 IRCT 2023-02-25 Tehran University of Medical Sciences Investigating the effectiveness of intra-articular injection painkillers after cruciate ligament surgery The Comparison between intraarticular knee injection (Morphine, ketorolac) with and without Tranxamic acid following arthroscopic ACL reconstruction surgery in reducing pain and assessing functional outcomes in patient with isolated ACL injury 2022-04-01 anticipated 100 Complete https://irct.ir/trial/67736 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Table of random numbers (four block) by site randomization.com, Blinding description: In our study, both the patients and the researchers are blinded to the prescription of the intervention drug, and the surgeon simply divides the patients into 2 groups, with and without the prescription of the drug, based on the argument of random numbers. 3 isolated anterior cruciate ligament injury. Intervention 1: Control group: Intra-articular injection of 40 cc of analgesic cocktail after surgery including: 30 mg Ketorolac ampoule (1 cc), 5 mg of morphine sulfate (0.5 cc),100 mg of lidocaine (5 cc), 33.5 cc of normal solution Saline; All made by Iranian pharmaceutical companies. Intervention 2: Intervention group: Intra-articular injection of 40 cc of analgesic cocktail after surgery including: 30 mg Ketorolac ampoule (1 cc), 5 mg of morphine sulfate (0.5 cc), 1 gram of tranexamic acid (TXA) (10 cc)100 mg of lidocaine (5 cc) 23.5 cc normal saline solution; All made by Iranian pharmaceutical companies. No - There is not a plan to make this available Justification or reason for not sharing IPD is ask for IPD through corresponding investigator