IRCT20230103057039N1 IRCT 2023-04-06 Islamic Azad University Evaluation of the efficacy of laser and plasma in the treatment of freckles Comparison of the plasma effect with and without alexandrite laser in the treatment of freckles in patients referred to the clinics affiliated with Tehran Medical Sciences Azad University in 2022-2023 2023-01-27 anticipated 60 Complete https://irct.ir/trial/67838 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The evaluation of the results of the interventions is done by a dermatologist and this study is blinded by her. N/A Patients with freckles. Intervention 1: The first intervention group: A group of 30 patients with fitzpatrick skin type 1 to 4 who had no history of using topical lightening drugs from 8 weeks before treatment, without sexual restriction, over 16 years old, will be treated with plasma single pass. The amount of skin pigmentation in two stages before and after treatment is determined. The response to treatment will be complete loss of lesions (recovery above 80%). Intervention 2: Second group of intervention: A group of 30 patients with fitzpatrick skin type 1 to 4 who had no history of using topical lightening drugs from 8 weeks before treatment, without sexual restriction ,over 16 years old will be treated with plasma single pass with a single pass laser shot with a wavelength of 755 nm with a wavelength of 5 mm and Pulse duration of 0.5 milisecond with Fluence = 20 J/cm2 for skin type 3 and 4 /Fluence = 24 J/cm2 for skin type 1 and 2 in single pass. The amount of skin pigmentation in two stages before and after treatment is determined. The response to treatment will be complete loss of lesions (recovery above 80%). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is NO more information