IRCT201105016345N1 IRCT 2011-06-22 Vice chancellor for research, Tehran University of Medical Sciences The effect of Bromocriptine rebound method on Intracytoplasmic sperm injection cycles outcome a randomized clinical trial to compare the effect of bromocriptine-rebound method on ongoing pregnancy and live birth after Intracytoplasmic sperm injection cycles with long protocol 2009-03-21 anticipated 114 Complete https://irct.ir/trial/6791 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 IVF/ICSI. Intervention 1: intervention : similar to long protocol except administration of Bromocriptine 2.5 mg per day since day 4 of follicular phase till 7 days before gonadotropine syimulation. Intervention 2: control : long protocol In preceding cycle, OCP was administered from day 3 for a month and Buserelin (Superfact, Aventis, Frankfurt, Germany) was started 0.5 mg daily from day 21. Then, ovarian hyper stimulation was initiated with recombinant FSH (Gonal F, Serono, and Aubnne, Switzerland) in different doses according to ovarian antral follicle count in sonography on day 2 of withdrawal bleeding. Serial ultrasound examinations were used to assess ovarian response, and then gonadotropin dose adjustments were done as required. Human chorionic gonadotropin (Pregnyl, Organon, Oss, the Netherlands) 10,000 IU was administered when at least two follicles reached a mean diameter of 18 mm. Oocytes retrieval was performed 36 hours after hCG administration and oocytes were inseminated with ICSI. Evidence for fertilization was assessed approximately 18 h after insemination. Embryo transfer was performed on day 2. Luteal support with progesterone in oil (Progesterone, Aburaihan Co., Tehran, Iran) 25 mg daily IM and vaginal suppository Cyclogest was started on the day of oocytes retrieval and continued until the documentation of fetal heart activity on ultrasound. Chemical pregnancy was assessed based on Beta HCG after 14-15 days . 6 weeks later clinical pregnancy was documented based on presence of intra uterine gestational sac in trans vaginal sonography and ongoing pregnancy was determined if normal pregnancy last for more than 16 weeks .