IRCT201312161059N2 IRCT 2014-05-11 Science Medical Vice chancellor for research, Pasteur Institute of Iran Efficacy evaluation of pomegranate peel extract in oral candidiasis treatment Comparison of Pomegranate peel extract anticandidal activity and nystatin in patients with oral candidiasis 2014-06-22 anticipated 60 Complete https://irct.ir/trial/68 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: This randomized clinical trial will be conducted between 22 May 2014 and 19 February 2015, comparing the effectiveness of pomegranate peel extract and nystatin in patients with oral candidiasis. After assessment of eligibility, sixty subjects will be included in this study. After the initial assessment patients by using the random number tables, will be randomly assigned to either an intervention group or a control-group. After randomization by using the random number tables, the two groups of subjects are followed in exactly the same way. 0 (exploratory trials) Oral Candidiasis. Intervention 1: Intervention 1: Pomegranate (Punica granatum L.) peel extract gel. The oral gel contains pomegranate peel extract. It will be prepare in Jaber Ebne Hayyan Pharmaceutical Company in 40 ml tubes and it will be use topical three times per day for 14 days. The combination of carbopol and hydroxypropyl methylcellulose will be used as a gel vehicle for pomegranate peel extract topical application. Intervention 2: Intervention 2: Nystatin The nystatin level is 1.72% w/w. The combination of carbopol and hydroxypropyl methylcellulose will be used as a gel vehicle for nystatin topical application. It will be prepare in Jaber Ebne Hayyan Pharmaceutical Company in 40 ml tubes and it will be use topical three times per day for 14 days.