IRCT20221120056556N1 IRCT 2023-01-24 Shahid Beheshti University of Medical Sciences Comparison of the effect of (NSIMV) Nasal Synchronized Intermittent Mandatory Ventilation whit (NHFOV) Nasal high frequency oscillatory ventilation in neonates requiring non-invasive mechanical ventilation in Mofid Pediatric Hospital Comparison of the effect of (NSIMV) Nasal Synchronized Intermittent Mandatory Ventilation whit (NHFOV) Nasal high frequency oscillatory ventilation in neonates requiring non-invasive mechanical ventilation in Mofid Pediatric Hospital 2023-02-20 anticipated 180 Complete https://irct.ir/trial/68095 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Premature babies needing non-invasive mechanical ventilation are divided into two non-invasive mechanical ventilation groups(HFO and SIMV) using simple randomization method and random number table. So that patients who met the criteria s to enter the study will be assigned a number, and then without prior knowledge, even numbers will be placed in the intervention group and odd numbers will be placed in the control group. In this way, each member of the community will have an equal chance to be selected in order to be included in both intervention and control groups, and the researcher will not interfere in the selection of samples, Blinding description: In this study, premature babies who need non-invasive mechanical ventilation will be divided into two groups. Due to the study method and the impossibility of blinding mechanical ventilation, the doctor and nurse caring for the baby will be informed about the selected method for non-invasive mechanical ventilation, but the statistical analyzer of the research will not be informed about the allocation of patients in two groups. 2 Respiratory Distress Syndrome/ Prematurity. Intervention group: Premature babies with a gestational age of more than 26 weeks need non-invasive mechanical ventilation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After starting the study and conducting the pilot, action will be taken to publish and make the study available