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IRCT20191106045356N18 IRCT 2023-07-25 Yazd University of Medical Sciences The effect of topical piroxicam in the treatment of uremic pruritus The effect of topical piroxicam in the treatment of uremic pruritus: A randomized double-blinded placebo control clinical trial 2023-03-06 anticipated 50 Complete https://irct.ir/trial/68097 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly assigned to one of the two groups of piroxicam gel and placebo based on the RAND function of Excel software in the order of entry into the study, Blinding description: The study will be done in a double-blind manner. Patients and doctors (therapist and evaluator) will not know about the intervention. Piroxicam gel and Base gel are numbered by one of the researchers who does not intervene in the study process (treatment, evaluation, and data analysis) with labels one and two, and only the same researcher knows about the numbering of worms. Then the numbered gels are delivered to the patients by the doctor. 3 Uremic pruritus. Intervention 1: Intervention group: 25 patients with uremic pruritus treated with 0.5% piroxicam gel (manufactured by a domestic pharmaceutical company), topical application, once a day for 14 days. Intervention 2: Control group: 25 patients with uremic itching who were treated with base gel (lubricant gel made by a domestic pharmaceutical company), topical application, once a day for 14 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences scientific Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) Patients undergoing hemodialysis more than 3 times a month Insensitivity to piroxicam Patients with chronic uremic pruritus Absence of pregnancy and breastfeeding 18 years 70 years Both Patients with underlying skin disease Allergic to Piroxicam Pregnancy L29 Pruritus Treatment - Drugs Placebo Intervention group: 25 patients with uremic pruritus treated with 0.5% piroxicam gel (manufactured by a domestic pharmaceutical company), topical application, once a day for 14 days. Control group: 25 patients with uremic itching who were treated with base gel (lubricant gel made by a domestic pharmaceutical company), topical application, once a day for 14 days. Uremic pruritus. Timepoint: ?Before intervention and 7, 14 days after intervention. Method of measurement: Pruritus questionnaire. Vice President of Research and Technology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Approved 2023-06-26 Ethics committee of Shahid Sadoughi University of Medical Sciences Alem sq. Yazd Yazd Iran (Islamic Republic of)