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IRCT20110823007402N9 IRCT 2023-01-23 Shiraz University of Medical Sciences Effect of nano hydroxyapatite toothpaste and mouthwash on enamel and dentin erosion Effect of nano hydroxyapatite toothpastes and mouth rinse on eroded enamel and dentin - an in situ study 2023-04-05 anticipated 21 Complete https://irct.ir/trial/68101 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple randomization, block. The size of all the blocks will be equal. Sequence generation software is also used for randomization. Sequentially numbered, sealed, opaque envelopes are used for random concealment. In this method, each random sequence created is recorded on a card and the cards inside and the letter envelopes are placed in order. In order to maintain a random sequence, the outer surface of the envelopes is numbered in the same order. Finally, the lid of the letter envelopes is glued and placed in a box. At the time of starting the registration of participants, based on the order in which eligible participants entered the study, one of the envelopes will be opened and the assigned group of that participant will be revealed, Blinding description: The size of all the blocks will be equal. Sequence generation software is also used for randomization. Sequentially numbered, sealed, opaque envelopes are used for random concealment. In this method, each random sequence created is recorded on a card and the cards inside and the letter envelopes are placed in order. In order to maintain a random sequence, the outer surface of the envelopes is numbered in the same order. Finally, the lid of the letter envelopes is glued and placed in a box. At the time of starting the registration of participants, based on the order in which eligible participants entered the study, one of the envelopes will be opened and the assigned group of that participant will be revealed. 3 enamel and dentin erosion. Intervention 1: The first intervention group (positive control): using Elmex ® erosion protection toothpaste (GABA International AG, Therwil, Switzerland) containing 3500 ppm of tin ions in the form of tin chloride and 1400 ppm of fluoride ions with pH = 4.5. followed by Elmex® erosion protection mouthwash containing 800 ppm of tin ions in the form of tin chloride and 500 ppm of fluoride ions with pH = 4.5. The second intervention group: using Vitis® anticaries toothpaste with nanorepair (VITIS Oral HealthC/O Dent- O-Care, London, UK) containing 1450 ppm fluoride ions in sodium monofluorophosphate, 0.45% nanohydroxyapatite and 10% xylitol. Then using Vitis® anticaries mouthwash containing 1450 ppm fluoride ions in sodium monofluorophosphate, 0.45% nanohydroxyapatite and 10% xylitol. Intervention 2: Control group: In this group, distilled water is used (appliance without using toothpaste). No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information exists
public Mahtab Memarpour
Dental school, Ghomabad, Ghasrodasht
Shiraz Iran (Islamic Republic of) 15878- 71956 +98 71 1626 3192 memarpour@sums.ac.ir Shiraz University of Medical Sciences scientific Mahtab Memarpour
Dental school, Ghomabad, Ghasrodasht
Shiraz Iran (Islamic Republic of) 15878- 71956 +98 71 1626 3192 memarpour@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) 1) Being at least 18 years old 2) Having good general and oral health 3) Not being allergic to certain substances including oral hygiene products or dental materials 4) Non-stimulated and stimulated saliva flow more than 0.25 ml/min and more than 0.25 ml/min, respectively. 5) The absence of active caries lesions or non-carious lesions such as cervical lesions and periodontal disease 6) The absence of dental prostheses and orthodontic appliances 7) The absence of erosive lesions in the teeth 8) The possibility of visiting at recalls. 18 years no limit Both 1) Pregnancy or intention to become pregnant during the study 2) Breastfeeding 3) Simultaneous participation in another study 4) Professional use of fluoride in the last two months 5) Inability to implement the study protocols 6) Receiving medical treatment 7) Using drugs that Interference with the flow of saliva 8) Having digestive problems 9) Smoking K03.2 Erosion of teeth Prevention Placebo The first intervention group (positive control): using Elmex ® erosion protection toothpaste (GABA International AG, Therwil, Switzerland) containing 3500 ppm of tin ions in the form of tin chloride and 1400 ppm of fluoride ions with pH = 4.5. followed by Elmex® erosion protection mouthwash containing 800 ppm of tin ions in the form of tin chloride and 500 ppm of fluoride ions with pH = 4.5. The second intervention group: using Vitis® anticaries toothpaste with nanorepair (VITIS Oral HealthC/O Dent- O-Care, London, UK) containing 1450 ppm fluoride ions in sodium monofluorophosphate, 0.45% nanohydroxyapatite and 10% xylitol. Then using Vitis® anticaries mouthwash containing 1450 ppm fluoride ions in sodium monofluorophosphate, 0.45% nanohydroxyapatite and 10% xylitol. Control group: In this group, distilled water is used (appliance without using toothpaste). Surface microhardness, roughness and surface wear. Timepoint: 5 days after the erosive/abrasive challenge. Method of measurement: Measuring surface wear with contact profilometry, surface hardness using Vickers test, surface roughness with atomic force microscope. Shiraz University of Medical Sciences Approved 2022-10-19 Ethics committee of Shiraz University of Medical Sciences Administration Building of Shiraz University of Medical Sciences Zand St., Shiraz, Iran Shiraz Fars Iran (Islamic Republic of)