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IRCT20230115057128N1 IRCT 2023-02-19 Ilam University of Medical Sciences comparison of the effectiveness of 5-FU and tacrolimus ointment in the treatment of vitiligo vulgaris comparison of the effectiveness of 5-FU and tacrolimus ointment in the treatment of vitiligo vulgaris 2023-01-21 anticipated 40 Complete https://irct.ir/trial/68166 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: In the questionnaire, each patient's lesion will be marked with code 1 and 2, and the researcher will not know the type of drug used in each location until the time of analysis.The patient does not know the type of medicine by giving the medicine in special containers. 2 vitiligo vulgaris. Intervention 1: Intervention group 1: For the first intervention group, the use of 0.1% tacrolimus topical ointment on body lesions will be prescribed twice a day (in the morning after waking up and at night before going to bed). Intervention 2: Intervention group 2: For the second intervention group, the use of 5-fluorouracil (FU-5) ointment on body lesions twice a day (in the morning after waking up and at night before going to bed) will be prescribed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Fatemeh Raoufi
Shahid 1 Alley, Mossali St., Justice Square, Ilam
Ilam Iran (Islamic Republic of) 6931475597 +98 84 3224 0029 dr.raoufi.f@gmail.com Ilam University of Medical Sciences scientific Fariba Shadfar
Imam Khomeini Hospital, Ayatollah Heydari Street, Ilam
Ilam Iran (Islamic Republic of) 6939177143 +98 84 3224 0029 faribashadfar03@gmail.com Ilam University of Medical Sciences Iran (Islamic Republic of) The presence of at least two vitiligo lesions in the upper, lower and trunk limbs similar in size and color (if the patient had several depigmented lesions, among them two lesions that were similar in size and color were selected would be) Age above 12 years have the possibility to refer and follow up Consent based on participating in the study Not using topical treatments in the last month The steady or progressive course of the disease in a person Occupancy of at least 10% of the body surface by this disease Not having an immune deficiency 12 years no limit Both Patients with skin lesions on the face Cases of segmental vitiligo pregnancy Inability to track treatment results L80 Vitiligo Treatment - Drugs Treatment - Drugs Intervention group 1: For the first intervention group, the use of 0.1% tacrolimus topical ointment on body lesions will be prescribed twice a day (in the morning after waking up and at night before going to bed). Intervention group 2: For the second intervention group, the use of 5-fluorouracil (FU-5) ointment on body lesions twice a day (in the morning after waking up and at night before going to bed) will be prescribed. Size of the lesion. Timepoint: Examining the lesions at the beginning of the study and the second, fourth and sixth months after the start of treatment. Method of measurement: VASI scoring system. Percentage of pigmentation. Timepoint: Examining the lesions at the beginning of the study and the second, fourth and sixth months after the start of treatment. Method of measurement: VASI scoring system. Ilam University of Medical Sciences Approved 2023-01-09 Ethics Committee of Ilam University of Medical Sciences Research and Technology Blvd., Ilam University of Medical Sciences campus, Banganjab, Ilam Ilam Ilam Iran (Islamic Republic of)