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IRCT20230128057257N1 IRCT 2023-02-05 Arak University of Medical Sciences Comparison of the effects of ginger, ondansetron and droperidol on nausea and vomiting after hysterectomy Comparison of the effects of ginger, ondansetron and droperidol on nausea and vomiting after hysterectomy 2023-01-31 anticipated 75 Complete https://irct.ir/trial/68317 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: All patients with the entry criteria will be divided into three equal groups using a randomized block method; for each of the patients, the drugs studied in three groups were prepared by the anesthesiologist and they were prepared in the form of syringes of the same shape and color and with the same volume, and only 1-2-3 labels were placed on them. Then it will be given to the anesthetist technician of the project (who does not know the type of drugs) to be injected into the patients, also the patients do not know the type of drugs received. Additionally, the intern in charge of the project, who is responsible for completing the project questionnaires after the surgery, is also not aware of the type of study groups, Blinding description: This is a double-blind study. Blinding of the participants was done using the same appearance of the drugs. Also, the patients did not have any information about which group they were assigned to. The blinding of the researcher was also done in such a way that one person delivered the medicine to a patient who did not know its type. 3 Postoperative nausea and vomiting. Intervention 1: Intervention group: ondansetron, one hour before surgery, 8 mg of ondansetron by injection. Intervention 2: Intervention group: droperidol, one hour before surgery, 2.5 mg droperidol injection. Intervention 3: Intervention group: Ginger, one hour before the operation, 4 ginger capsules, each containing 250 mg of ginger. No - There is not a plan to make this available Justification or reason for not sharing IPD is In order to protect the privacy and personal information of the patient, the non-disclosure of personal information and other such information is mentioned in the informed consent form to obtain the consent of the patient and her family.
public Reza Latifi
Jannat street, Shariati Blvd.
Arak Iran (Islamic Republic of) 3813695519 +98 86 3412 0065 dr.r.latifi@gmail.com Arak University of Medical Sciences scientific Maryam Shokrpour
Taleghani Educational Medical Center, West Imam Khomeini Street
Arak Iran (Islamic Republic of) 3816149369 +98 86 3277 6063 maryam_shokrpour@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Candidate for hysterectomy surgery Willingness to participate in the study after obtaining informed consent Age between 18-60 years The ability to swallow the capsules used in the study Platelet count above 100000 18 years 60 years Female Having cancer Hypertension Intestinal obstruction and hepatitis Taking anti-nausea and vomiting drugs or drugs that cause it Long-term treatment with corticosteroid drugs Ginger allergy history Use of blood thinners and anticoagulants before surgery Prevention Prevention Prevention Intervention group: ondansetron, one hour before surgery, 8 mg of ondansetron by injection Intervention group: droperidol, one hour before surgery, 2.5 mg droperidol injection Intervention group: Ginger, one hour before the operation, 4 ginger capsules, each containing 250 mg of ginger. The amount of nausea and vomiting after surgery. Timepoint: 2, 4, and 6 hours after surgery. Method of measurement: Visual Analogue Scale. Arak University of Medical Sciences Approved 2022-12-11 Ethics committee of Arak University of Medical Sciences A'lam-Al-Hoda Street, Shahid Shiroodi Street, Arak, Markazi Province, Iran Arak Markazi Iran (Islamic Republic of)