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IRCT20220317054318N2 IRCT 2023-02-08 Hamedan University of Medical Sciences Investigating the effect of PRP in oligospermia Evaluate the effect of platelet-rich plasma(PRP) by testicular injection on spermogram parameters of infertile men with sever oligoasthenoteratozoospermia (OAT) 2023-02-20 anticipated 88 Complete https://irct.ir/trial/68439 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The study has two intervention groups and a control group, the intervention group receives platelet-rich plasma and the control group receives placebo, Randomization description: In the first stage, the selection of those eligible to enter the study is done in an easy and accessible way, but after the selection of those eligible to enter the study, the participants are randomly divided into two intervention and control groups. Randomization is done by block method. In this way, we prepare 18 sheets of paper and write the letter A on 9 sheets and the letter B on the other 9 sheets. In the study, one of the sheets is taken out randomly and according to whether it is group A or B, it is assigned to the intervention and control group, and the sheets drawn out do not return to the drawer until all 18 sheets have been drawn, and after completion 18 sheets are returned to the drawer and the above operation is repeated until the number of samples is complete, Blinding description: In this study, the people participating in the study are kept blind and do not obey the treatment process. 3 Oligostenoteratozoospermia. Intervention 1: Intervention group:including 44 patients who were injected with 2cc of platelet-rich plasma by the urologist inside their testicles. Intervention 2: Control group:44 patients who do not undergo any intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public SHamim Pilehvary
Pasdaran Street
Hamedan Iran (Islamic Republic of) 6517789971 +98 81 3834 0266 Sh.pilevar@umsha.ac.ir Hamedan University of Medical Sciences scientific SHamim Pilehvary
Pasdaran Street
Hamedan Iran (Islamic Republic of) 6517789971 +98 81 3834 0266 Sh.pilevar@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Age range 20-45 years. sperm count less than 20 million, Movement less than 106 x 5 ml, progressive movement < 20%, normal morphology < 10% 20 years 45 years Male Receiving other treatments for oligospermia such as hormone therapy Suffering from underlying diseases (such as diabetes, kidney disease, liver disease, drug and alcohol addiction) and types of cancer and receiving chemotherapy treatments N46 Male infertility Treatment - Surgery Other Intervention group:including 44 patients who were injected with 2cc of platelet-rich plasma by the urologist inside their testicles Control group:44 patients who do not undergo any intervention Sperm count and motility in men. Timepoint: 3 months after intratesticular platelet rich plasma injection. Method of measurement: Sperm analysis, DNA fragmentation index. Hamedan University of Medical Sciences Approved 2023-01-28 Ethics Committee of Hamadan University of Medical Sciences Pasdaran street Hamedan Hamadan Iran (Islamic Republic of)